Structural view of the Ran-Importin beta interaction at 2.3 A resolution (Q27618579)

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A Arndt

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U Kutay

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A Wittinghofer

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope

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language of work or name

English

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publication date

28 May 1999

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published in

Cell

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volume

97

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page(s)

635-46

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issue

5

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cites work

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Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide

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Sequence and characterization of cytoplasmic nuclear protein import factor p97

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Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97

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Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line

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The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein

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Disassembly of RanGTP-karyopherin beta complex, an intermediate in nuclear protein import.

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CRM1 is an export receptor for leucine-rich nuclear export signals

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The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

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Isolation of a protein that is essential for the first step of nuclear protein import

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Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

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A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus

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A novel class of RanGTP binding proteins

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Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta

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A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells

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Structural basis for the interaction of Ras with RalGDS

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Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue

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The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile.

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The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

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Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

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Electron-density map interpretation

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Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex

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Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor

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Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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Ras/Rap effector specificity determined by charge reversal

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA

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Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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A repeating amino acid motif shared by proteins with diverse cellular roles

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X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis

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Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins

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The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller

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Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

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The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1

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Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

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7 January 2021

Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr

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7 January 2021

Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins

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Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran

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The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals

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7 January 2021

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

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Crystal structure of RhoA-GDP and its functional implications

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The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import

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