Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1 (Q24311327)

guanyl-nucleotide exchange factor activity

GOA release 2020-03-11

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guanine

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author name string

F R Bischoff

series ordinal

1

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H Ponstingl

series ordinal

2

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language of work or name

English

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publication date

7 November 1991

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published in

Nature

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volume

354

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page(s)

80-2

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issue

6348

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cites work

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis

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Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product.

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The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1

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A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation

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Molecular cloning of a human gene that regulates chromosome condensation and is essential for cell proliferation

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Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation

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The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA

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A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation

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A cytosolic protein catalyzes the release of GDP from p21ras

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The GTPase superfamily: conserved structure and molecular mechanism

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Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase

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