The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system (Q39941077)

15 September 2017

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system (English)

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15 September 2017

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6

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15 September 2017

Laura E Randle

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author name string

Ian M Copple

1

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15 September 2017

Christopher E Goldring

2

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15 September 2017

Rosalind E Jenkins

3

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15 September 2017

Alvin J L Chia

4

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15 September 2017

Neil R Kitteringham

7

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15 September 2017

B Kevin Park

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15 September 2017

language of work or name

English

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publication date

1 October 2008

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15 September 2017

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15 September 2017

48

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15 September 2017

4

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15 September 2017

1292-1301

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Drug-induced hepatotoxicity.

15 September 2017

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Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study

21 January 2018

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The molecular toxicology of acetaminophen

21 January 2018

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Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

21 January 2018

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The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity

21 January 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

21 January 2018

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

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Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

21 January 2018

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Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

21 January 2018

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Sites of alkylation of human Keap1 by natural chemoprevention agents

21 January 2018

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Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

21 January 2018

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Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

21 January 2018

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

21 January 2018

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Acetaminophen hepatotoxicity: the first 35 years

21 January 2018

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An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

21 January 2018

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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

21 January 2018

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

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Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

21 January 2018

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Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention

21 January 2018

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Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

21 January 2018

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Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells.

21 January 2018

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Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

21 January 2018

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Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

21 January 2018

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Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Genetic variations and haplotype structures of transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/HEP.22472

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15 September 2017

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