Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics (Q26822002)

Grant A Krafft

series ordinal

2

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Jasna Jerecic

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3

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Franz Hefti

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4

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language of work or name

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2014

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Alzheimers Research & Therapy

published in

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volume

6

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page(s)

42

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issue

4

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Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

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Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

7 April 2017

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Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

7 April 2017

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Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils

7 April 2017

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Reversal of long-term dendritic spine alterations in Alzheimer disease models

7 April 2017

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Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

7 April 2017

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

7 April 2017

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

7 April 2017

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

7 April 2017

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

7 April 2017

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beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

7 April 2017

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Structural basis of C-terminal β-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease

7 April 2017

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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

7 April 2017

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

7 April 2017

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Direct observation of single amyloid-β(1-40) oligomers on live cells: binding and growth at physiological concentrations

7 April 2017

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Abeta mediated diminution of MTT reduction--an artefact of single cell culture?

7 April 2017

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Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

7 April 2017

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

7 April 2017

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Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation

7 April 2017

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Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease

7 April 2017

1 reference

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Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

7 April 2017

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

7 April 2017

1 reference

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A specific amyloid-beta protein assembly in the brain impairs memory

7 April 2017

1 reference

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

7 April 2017

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

7 April 2017

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

7 April 2017

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

7 April 2017

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A beta oligomers - a decade of discovery

7 April 2017

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

7 April 2017

1 reference

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

7 April 2017

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

7 April 2017

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Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease

7 April 2017

1 reference

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Amyloid β-protein oligomers and Alzheimer's disease

28 September 2017

1 reference

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Treating Alzheimer's disease with monoclonal antibodies: current status and outlook for the future

28 September 2017

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Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

28 September 2017

1 reference

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On the subject of rigor in the study of amyloid β-protein assembly

28 September 2017

1 reference

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A Luminex assay detects amyloid β oligomers in Alzheimer's disease cerebrospinal fluid

28 September 2017

1 reference

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Evaluating amyloid-β oligomers in cerebrospinal fluid as a biomarker for Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

NMDA-receptor activation but not ion flux is required for amyloid-beta induced synaptic depression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Developing therapeutic antibodies for neurodegenerative disease

28 September 2017

1 reference

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Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis

28 September 2017

1 reference

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Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes

28 September 2017

1 reference

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Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells

28 September 2017

1 reference

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The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers

28 September 2017

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Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls

28 September 2017

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Soluble aβ promotes wild-type tau pathology in vivo

28 September 2017

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The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

28 September 2017

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Isolated amyloid-β(1-42) protofibrils, but not isolated fibrils, are robust stimulators of microglia

28 September 2017

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Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory.

28 September 2017

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Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM

28 September 2017

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Amyloid-β peptide: Dr. Jekyll or Mr. Hyde?

28 September 2017

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Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay

28 September 2017

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Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease

28 September 2017

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The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain

28 September 2017

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Targeting Beta amyloid: a clinical review of immunotherapeutic approaches in Alzheimer's disease

28 September 2017

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

28 September 2017

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Oligomeric intermediates in amyloid formation: structure determination and mechanisms of toxicity

28 September 2017

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Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice

28 September 2017

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Soluble Aβ oligomer production and toxicity

28 September 2017

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Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation

28 September 2017

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New developments on the role of NMDA receptors in Alzheimer's disease

28 September 2017

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The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

28 September 2017

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Aβ oligomer-induced synapse degeneration in Alzheimer's disease

28 September 2017

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Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

28 September 2017

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Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

28 September 2017

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Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity.

28 September 2017

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Preparing synthetic Aβ in different aggregation states

28 September 2017

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The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

28 September 2017

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Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

28 September 2017

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28 September 2017

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Endocytic pathways mediating oligomeric Abeta42 neurotoxicity.

28 September 2017

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An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies

28 September 2017

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11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

28 September 2017

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Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

28 September 2017

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Amyloid oligomers: formation and toxicity of Abeta oligomers

28 September 2017

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Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

28 September 2017

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Aβ oligomers inhibit synapse remodelling necessary for memory consolidation

28 September 2017

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Amyloid beta from axons and dendrites reduces local spine number and plasticity.

28 September 2017

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Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption

28 September 2017

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Cognitive effects of cell-derived and synthetically derived Aβ oligomers

28 September 2017

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A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

28 September 2017

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Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

28 September 2017

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Alzheimer's disease amyloid beta-protein and synaptic function

28 September 2017

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Structure-neurotoxicity relationships of amyloid beta-protein oligomers

28 September 2017

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Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.

28 September 2017

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Amyloid deposits: protection against toxic protein species?

28 September 2017

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Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

28 September 2017

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Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

28 September 2017

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Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

28 September 2017

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Amyloid beta-protein assembly and Alzheimer disease

28 September 2017

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Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease

28 September 2017

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Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases

28 September 2017

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Structural classification of toxic amyloid oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Natural human antibodies to amyloid beta peptide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Sensitive ELISA detection of amyloid-beta protofibrils in biological samples

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Solution state characterization of amyloid beta-derived diffusible ligands

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Kinetics and thermodynamics of amyloid fibril assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

The development of amyloid beta protein deposits in the aged brain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Strategies for disease modification in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Alzheimer's amyloid fibrils: structure and assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Molecular modeling of the Abeta1-42 peptide from Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Globular and protofibrillar aβ aggregates impair neurotransmission by different mechanisms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

31 May 2018

1 reference

An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.

21 January 2018

1 reference

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

21 January 2018

1 reference

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.

21 January 2018

1 reference

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

21 January 2018

1 reference

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

21 January 2018

1 reference

Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.

21 January 2018

1 reference

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

21 January 2018

1 reference

Abeta-globulomers are formed independently of the fibril pathway

21 January 2018

1 reference

Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease.

21 January 2018

1 reference

Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.

21 January 2018

1 reference

High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients.

21 January 2018

1 reference

A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid.

21 January 2018

1 reference

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

21 January 2018

1 reference

Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation

21 January 2018

1 reference

The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

21 January 2018

1 reference

Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition

21 January 2018

1 reference

Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.

21 January 2018

1 reference

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

21 January 2018

1 reference

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

21 January 2018

1 reference

Beta-amyloid monomers are neuroprotective.

21 January 2018

1 reference

Prefibrillar amyloid aggregates could be generic toxins in higher organisms.

21 January 2018

1 reference

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

21 January 2018

1 reference

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.

21 January 2018

1 reference

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

21 January 2018

1 reference

Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

21 January 2018

1 reference

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

21 January 2018

1 reference

Neurotoxic protein oligomers--what you see is not always what you get.

21 January 2018

1 reference

Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor.

21 January 2018

1 reference

Sortilin is required for toxic action of Aβ oligomers (AβOs): extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways.

21 January 2018

1 reference

The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity.

21 January 2018

1 reference

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

21 January 2018

1 reference

Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner

21 January 2018

1 reference

Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.

21 January 2018

1 reference

Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide

21 January 2018

1 reference

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.

21 January 2018

1 reference

Safety and biomarker effects of solanezumab in patients with Alzheimer's disease.

21 January 2018

1 reference

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease

21 January 2018

1 reference

Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta.

21 January 2018

1 reference

Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

Immunotherapy reduces vascular amyloid-beta in PDAPP mice.

21 January 2018

1 reference

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

21 January 2018

1 reference

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab.

21 January 2018

1 reference

Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.

21 January 2018

1 reference

Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients.

21 January 2018

1 reference

Monoclonal antibodies that target pathological assemblies of Abeta.

21 January 2018

1 reference

Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

21 January 2018

1 reference

In-situ atomic force microscopy study of β-amyloid fibrillization

21 January 2018

1 reference

Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Amyloid-β oligomers in cerebrospinal fluid are associated with cognitive decline in patients with Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Amyloid-beta(1-42) rapidly forms protofibrils and oligomers by distinct pathways in low concentrations of sodium dodecylsulfate.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Self-assembly of Abeta(1-42) into globular neurotoxins.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100318

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

28 November 2018

1 reference

12 December 2020

High-resolution atomic force microscopy of soluble Abeta42 oligomers

1 reference

12 December 2020

2013 Alzheimer's disease facts and figures

1 reference

12 December 2020

Initiation and propagation of neurodegeneration

1 reference

12 December 2020

Aβ40 and Aβ42 Amyloid Fibrils Exhibit Distinct Molecular Recycling Properties

1 reference

12 December 2020

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

12 December 2020

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

1 reference

12 December 2020

Identifiers

DOI

10.1186/ALZRT272

1 reference

Dimensions Publication ID

2466771

1047003180

0 references

Fatcat ID

release_3kwfs2sprfct3as5jqpqiuatty

0 references

2466771

1 reference

1 reference

1 reference