Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets (Q26795735)

Milena Casula

4

0 references

Panagiotis Paliogiannis

Panagiotis Paliogiannis

7

0 references

Giuseppe Palmieri

Giuseppe Palmieri

1

0 references

Paolo Antonio Ascierto

8

Paolo Antonio Ascierto

0 references

Antonella Manca

6

Antonio Giuseppe Maria Cossu

Antonella Manca

0 references

9

Antonio Cossu

0 references

Maria Colombino

3

Maria Colombino

0 references

Maria Cristina Sini

5

MariaCristina Sini

0 references

language of work or name

English

0 references

publication date

2015

0 references

published in

Frontiers in Oncology

1 reference

POT1 loss-of-function variants predispose to familial melanoma

volume

5

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page(s)

183

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cites work

1 reference

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A landscape of driver mutations in melanoma

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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

7 April 2017

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

7 April 2017

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

7 April 2017

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7 April 2017

Main roads to melanoma

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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

7 April 2017

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Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme

7 April 2017

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

7 April 2017

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POT1 as a terminal transducer of TRF1 telomere length control

7 April 2017

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Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis

7 April 2017

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Beyond BRAF: where next for melanoma therapy?

7 April 2017

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

7 April 2017

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Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors

7 April 2017

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Improved overall survival in melanoma with combined dabrafenib and trametinib

7 April 2017

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Combined vemurafenib and cobimetinib in BRAF-mutated melanoma

7 April 2017

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Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

7 April 2017

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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition

7 April 2017

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Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

7 April 2017

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BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation

7 April 2017

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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012

7 April 2017

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

7 April 2017

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Autophagy in the Pathogenesis of Disease

7 April 2017

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Mutations of the BRAF gene in human cancer

7 April 2017

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The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma

7 April 2017

1 reference

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Targeting RAS signalling pathways in cancer therapy

7 April 2017

1 reference

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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

MITF: master regulator of melanocyte development and melanoma oncogene

7 April 2017

1 reference

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Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF

7 April 2017

1 reference

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Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma

7 April 2017

1 reference

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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

7 April 2017

1 reference

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Autophagosome formation: core machinery and adaptations

7 April 2017

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Highly recurrent TERT promoter mutations in human melanoma

7 April 2017

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TERT promoter mutations in familial and sporadic melanoma

7 April 2017

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

7 April 2017

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

7 April 2017

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

7 April 2017

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

7 April 2017

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

7 April 2017

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Final version of 2009 AJCC melanoma staging and classification

7 April 2017

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How shelterin protects mammalian telomeres

7 April 2017

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Distinct sets of genetic alterations in melanoma

7 April 2017

1 reference

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

7 April 2017

1 reference

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

7 April 2017

1 reference

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The RAF proteins take centre stage

7 April 2017

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

7 April 2017

1 reference

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Long-term outcome in BRAF(V600E) melanoma patients treated with vemurafenib: Patterns of disease progression and clinical management of limited progression

7 April 2017

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Targeting drivers of melanoma with synthetic small molecules and phytochemicals

28 September 2017

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Cell cycle control as a promising target in melanoma

28 September 2017

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EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma

28 September 2017

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Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype

28 September 2017

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MiR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1.

28 September 2017

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The melanoma revolution: from UV carcinogenesis to a new era in therapeutics.

28 September 2017

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Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013.

28 September 2017

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Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy.

28 September 2017

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Profile of selumetinib and its potential in the treatment of melanoma

28 September 2017

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Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma

28 September 2017

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Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma

28 September 2017

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Role of the MEK inhibitor trametinib in the treatment of metastatic melanoma

28 September 2017

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Systemic treatment for BRAF-mutant melanoma: where do we go next?

28 September 2017

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AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment

28 September 2017

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Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide).

28 September 2017

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Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: promise and challenges

28 September 2017

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SWI/SNF chromatin remodeling enzymes in melanocyte differentiation and melanoma

28 September 2017

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EZH2: an emerging role in melanoma biology and strategies for targeted therapy.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Discrepant alterations in main candidate genes among multiple primary melanomas

28 September 2017

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Is it time to test biguanide metformin in the treatment of melanoma?

28 September 2017

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A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors

28 September 2017

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Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

28 September 2017

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Genetic alterations and personalized medicine in melanoma: progress and future prospects

28 September 2017

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Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma.

28 September 2017

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Oncogenes in melanoma: an update

28 September 2017

1 reference

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Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype

28 September 2017

1 reference

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Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

28 September 2017

1 reference

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The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma

28 September 2017

1 reference

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Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma

28 September 2017

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Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases

28 September 2017

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The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma

28 September 2017

1 reference

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Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma

28 September 2017

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MEK inhibition in the treatment of advanced melanoma

28 September 2017

1 reference

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Dermatologic toxicities to targeted cancer therapy: shared clinical and histologic adverse skin reactions.

28 September 2017

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Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Antiproliferative effects of continued mitogen-activated protein kinase pathway inhibition following acquired resistance to BRAF and/or MEK inhibition in melanoma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

MEK and the inhibitors: from bench to bedside

28 September 2017

1 reference

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Context-specific regulation of cancer epigenomes by histone and transcription factor methylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Targeting BRAF in melanoma: biological and clinical challenges

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Which drug, and when, for patients with BRAF-mutant melanoma?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

New developments in biomarkers for melanoma

28 September 2017

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An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

NRAS mutant melanoma: biological behavior and future strategies for therapeutic management

28 September 2017

1 reference

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BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Aurora A kinase (AURKA) in normal and pathological cell division

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Genetics and epigenetics of cutaneous malignant melanoma: a concert out of tune.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

From genes to drugs: targeted strategies for melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Regulation of MMPs during melanoma progression: from genetic to epigenetic

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Epigenetic biomarkers in skin cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Pattern formation in centrosome assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Role and therapeutic potential of PI3K-mTOR signaling in de novo resistance to BRAF inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Molecular Network Associated with MITF in Skin Melanoma Development and Progression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Melanoma and epigenetic treatment: past and future

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Met receptor: a moving target

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

In vitro and in vivo anti-melanoma action of metformin.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Expression of the c-Met Proteins in Malignant Skin Cancers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

STAT3 mediates resistance to MEK inhibitor through microRNA miR-17.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Transcriptional control of melanoma metastasis: the importance of the tumor microenvironment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Shared and separate functions of polo-like kinases and aurora kinases in cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Metformin and other biguanides in oncology: advancing the research agenda

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Cancer stem cells versus phenotype-switching in melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Overview of macroautophagy regulation in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Mutation-driven drug development in melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Polyclonality of BRAF mutations in acquired melanocytic nevi

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Genetic risk factors for melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Understanding melanoma signaling networks as the basis for molecular targeted therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

A multi-marker assay to distinguish malignant melanomas from benign nevi

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

c-KIT signaling as the driving oncogenic event in sub-groups of melanomas

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Control of autophagy by oncogenes and tumor suppressor genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

RAS: target for cancer therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

The role of p53 in pigmentation, tanning and melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

The Aurora kinase family in cell division and cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

In vivo switching of human melanoma cells between proliferative and invasive states

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Issues affecting molecular staging in the management of patients with melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

BRAF somatic mutations in malignant melanoma and melanocytic naevi

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Histone deacetylase inhibitors and malignant melanoma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Oncogenic Ras in tumour progression and metastasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Melanocytes and the microphthalmia transcription factor network

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

High frequency of BRAF mutations in nevi

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Genome-wide analysis of noncoding regulatory mutations in cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4530319

Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma.

31 May 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

KIT gene mutations and copy number in melanoma subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

Clinical characteristics and outcomes with specific BRAF and NRAS mutations in patients with metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

A STATement on vemurafenib-resistant melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

JARID1B expression in human melanoma and benign melanocytic skin lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

Targeting the epigenome for treatment of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF-Mutant Metastatic Melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

Anti-PD1 and anti-PD-L1 in the treatment of metastatic melanoma.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26322273

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

1 reference

https://api.crossref.org/works/10.3389%2FFONC.2015.00183

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.3389/FONC.2015.00183

1 reference

4825277

4825277

1 reference

1 reference

1 reference