Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics (Q26795417)

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English	Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics	scientific article

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25 April 2019

12 October 2019

Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics (English)

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neurodegeneration

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25 April 2019

12 October 2019

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12 October 2019

Levente Szalardy

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Dénes Zádori

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Oxidative medicine and cellular longevity

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Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders

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Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

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7 April 2017

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

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PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

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7 April 2017

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha

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7 April 2017

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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7 April 2017

Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

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7 April 2017

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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7 April 2017

The maintenance of mitochondrial DNA integrity--critical analysis and update

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7 April 2017

The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants

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7 April 2017

On the origin of mitosing cells

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7 April 2017

Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis

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7 April 2017

Nitrite reductase activity of cytochrome c

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7 April 2017

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

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7 April 2017

Huntington's disease

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7 April 2017

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

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7 April 2017

Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis

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7 April 2017

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

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7 April 2017

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

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7 April 2017

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

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7 April 2017

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2

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7 April 2017

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

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7 April 2017

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

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7 April 2017

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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7 April 2017

Chemiosmotic hypothesis of oxidative phosphorylation

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7 April 2017

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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7 April 2017

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

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7 April 2017

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

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7 April 2017

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

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7 April 2017

The PINK1/Parkin pathway regulates mitochondrial morphology

1 reference

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7 April 2017

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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7 April 2017

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

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7 April 2017

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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7 April 2017

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

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7 April 2017

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

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7 April 2017

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

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7 April 2017

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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7 April 2017

The mitochondrial permeability transition pore and its role in cell death

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7 April 2017

Parkinson's disease. First of two parts

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7 April 2017

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

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7 April 2017

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

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7 April 2017

Treadmill training increases SIRT-1 and PGC-1 α protein levels and AMPK phosphorylation in quadriceps of middle-aged rats in an intensity-dependent manner

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28 September 2017

Genetics of Parkinson's disease--state of the art, 2013.

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28 September 2017

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

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28 September 2017

TRAP1 rescues PINK1 loss-of-function phenotypes

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28 September 2017

Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease

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28 September 2017

Kynurenines in the CNS: recent advances and new questions.

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28 September 2017

Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf

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28 September 2017

Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α

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28 September 2017

Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening

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28 September 2017

Mitochondria, oxidative stress and neurodegeneration.

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28 September 2017

Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease

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28 September 2017

Mitochondrial disturbances, tryptophan metabolites and neurodegeneration: medicinal chemistry aspects.

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28 September 2017

8OHdG as a marker for Huntington disease progression

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28 September 2017

Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse

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28 September 2017

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

1 reference

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28 September 2017

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease

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28 September 2017

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease

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28 September 2017

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease.

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28 September 2017

Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease

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28 September 2017

Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease

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28 September 2017

Poly(ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription.

1 reference

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28 September 2017

DJ-1 regulation of mitochondrial function and autophagy through oxidative stress

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28 September 2017

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice

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28 September 2017

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

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28 September 2017

Dementia, stroke and migraine--some common pathological mechanisms.

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28 September 2017

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

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28 September 2017

Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome

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28 September 2017

Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

1 reference

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28 September 2017

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

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28 September 2017

Glutamate receptors, neurotoxicity and neurodegeneration

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28 September 2017

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

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28 September 2017

Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein

1 reference

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28 September 2017

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

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28 September 2017

EFNS guidelines on the molecular diagnosis of mitochondrial disorders

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28 September 2017

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

1 reference

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28 September 2017

PGC-1alpha activation as a therapeutic approach in mitochondrial disease

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28 September 2017

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

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28 September 2017

Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases

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28 September 2017

Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia

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28 September 2017

Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults.

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28 September 2017

PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Normal mitochondrial respiratory function is essential for spatial remote memory in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

RETRACTED: Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Complex I deficiency in Parkinson's disease frontal cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Neuropathology of mitochondrial diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Parkin enhances mitochondrial biogenesis in proliferating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial ND5 mutations in idiopathic Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

The ETS transcription factor GABPalpha is essential for early embryogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Neuropathological aspects of mitochondrial DNA disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Oligodendrocytes and ischemic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Neuropathological features of mitochondrial disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Replicating Huntington's disease phenotype in experimental animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Parkinson's disease. Second of two parts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Origin and functional consequences of the complex I defect in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Neuropathology of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial DNA sequence variation in human evolution and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Aging, energy, and oxidative stress in neurodegenerative diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Mitochondrial decay in aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Neuropathology and pathogenesis of mitochondrial diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 September 2017

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Regulation of mitochondrial permeability transition pore by PINK1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Tissue-specific regulation of SIRT1 by calorie restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Oxidative stress in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Biochemical abnormalities in Huntington's chorea brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

31 May 2018

mRNA expression levels of PGC-1α in a transgenic and a toxin model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Downregulation of parkin damages antioxidant defenses and enhances proteasome inhibition-induced toxicity in PC12 cells

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Early-onset familial parkinsonism due to POLG mutations.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Creatine and cyclocreatine attenuate MPTP neurotoxicity.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Glutamate uptake is reduced in prefrontal cortex in Huntington's disease

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Mitochondrial defect in Huntington's disease caudate nucleus

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Atmospheric polycyclic aromatic hydrocarbons (PAHs) in Asia: a review from 1999 to 2004.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Basal ganglia degeneration, myelin alterations, and enzyme inhibition induced in mice by the plant toxin 3-nitropropanoic acid

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Expression of polyglutamine-expanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor-Upsilon (PPARUpsilon) in Huntington's disease

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Neuroprotective effects of L-carnitine in a transgenic animal model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F498401

21 January 2018

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 November 2018

Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 November 2018

Similarities and differences between MPTP-induced parkinsonsim and Parkinson's disease. Neuropathologic considerations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 November 2018

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537740

28 November 2018

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivati

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitrite reductase activity is a novel function of mammalian mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of pioglitazone, a PPARγ ligand, in a 3 nitropropionic acid model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26301042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2015/498401

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26301042%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26301042%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26301042%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

ResearchGate publication ID

0 references

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