6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling (Q26781896)

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27 February 2020

title

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling (English)

1 reference

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27 February 2020

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1 reference

3 April 2019

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28 September 2019

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20 November 2019

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8 February 2021

1

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27 February 2020

Changliang Shan

3

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27 February 2020

Qun-Ying Lei

30

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28

Fadlo R Khuri

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27 February 2020

33

Titus J Boggon

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27 February 2020

17

Ralph J DeBerardinis

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27 February 2020

14

Jessica Sudderth

1 reference

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27 February 2020

4

Hee-Bum Kang

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27 February 2020

35

Sumin Kang

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27 February 2020

2

Shannon Elf

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27 February 2020

23

Georgia Zhuo Chen

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27 February 2020

author name string

Quanjiang Ji

5

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27 February 2020

Lu Zhou

6

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27 February 2020

Taro Hitosugi

7

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27 February 2020

Liang Zhang

8

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27 February 2020

Shuai Zhang

9

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27 February 2020

Jae Ho Seo

10

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27 February 2020

Jianxin Xie

11

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27 February 2020

Meghan Tucker

12

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27 February 2020

Ting-Lei Gu

13

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Lei Jiang

15

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27 February 2020

Matthew Mitsche

16

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27 February 2020

Shaoxiong Wu

18

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27 February 2020

Yuancheng Li

19

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27 February 2020

Hui Mao

20

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27 February 2020

Peng R Chen

21

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27 February 2020

Dongsheng Wang

22

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27 February 2020

Selwyn J Hurwitz

24

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Martha L Arellano

26

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Hanna J Khoury

27

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Benjamin H Lee

29

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27 February 2020

Daniel J Brat

31

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27 February 2020

Keqiang Ye

32

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27 February 2020

Chuan He

34

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27 February 2020

Jun Fan

36

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27 February 2020

Jing Chen

37

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Sagar Lonial

25

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publication date

19 October 2015

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27 February 2020

1 November 2015

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8 February 2021

language of work or name

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5 references

3 April 2019

28 September 2019

20 November 2019

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27 February 2020

8 February 2021

17

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27 February 2020

issue

11

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27 February 2020

page(s)

1484-1496

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publication type of scholarly work

27 February 2020

1 reference

8 February 2021

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

7 April 2017

1 reference

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

On the Origin of Cancer Cells

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

7 April 2017

Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Regulation of cancer cell metabolism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Importance of Glucose-6-phosphate Dehydrogenase Activity for Cell Growth

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Importance of glucose-6-phosphate dehydrogenase activity in cell death

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

7 April 2017

1 reference

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

22 April 2017

1 reference

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

22 April 2017

1 reference

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

22 April 2017

1 reference

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Tumor cell metabolism: cancer's Achilles' heel

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

7 April 2017

1 reference

Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

A new G6PD knockdown tumor-cell line with reduced proliferation and increased susceptibility to oxidative stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Critical phosphorylation sites for acetyl-CoA carboxylase activity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Mitogenic action of insulin-like growth factor-I on human osteosarcoma MG-63 cells and rat osteoblasts maintained in situ: the role of glucose-6-phosphate dehydrogenase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4628560

Glycolytic cancer cells lacking 6‐phosphogluconate dehydrogenase metabolize glucose to induce senescence

31 May 2018

1 reference

Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells

21 January 2018

1 reference

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

21 January 2018

1 reference

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

21 January 2018

1 reference

Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth

21 January 2018

1 reference

Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation.

21 January 2018

1 reference

Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells.

21 January 2018

1 reference

Critical role of Arg433 in rat transketolase activity as probed by site-directed mutagenesis

21 January 2018

1 reference

A novel assay system for the measurement of transketolase activity using xylulokinase from Saccharomyces cerevisiae

21 January 2018

1 reference

Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the γ1 subunit.

21 January 2018

1 reference

Regulation of hepatic phosphofructokinase by 6-phosphogluconate

21 January 2018

1 reference

12 December 2020

Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase

1 reference

12 December 2020

Relationships between UMPK and PGD activities and deletions of chromosome 1p in colorectal cancers

1 reference

12 December 2020

Alterations in erythrocyte glutathione metabolism associated with cervical dysplasias and carcinoma in situ

1 reference

12 December 2020

High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCB3255

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26479318%20AND%20SRC:MED&resulttype=core&format=json

Dimensions publication ID

27 February 2020

1004052792

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26479318%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

PubMed publication ID

26479318

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26479318%20AND%20SRC:MED&resulttype=core&format=json