Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target? (Q26774957)

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8 February 2021

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target? (English)

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author name string

Wen Zhang

series ordinal

1

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3 March 2020

Shao-Lin Zhang

series ordinal

2

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3 March 2020

Xiaohui Hu

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3

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language of work or name

English

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publication date

1 November 2015

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3 March 2020

8 February 2021

International Journal of Biological Sciences

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3 April 2019

28 September 2019

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issue

12

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page(s)

1390-1400

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Targeting cellular metabolism to improve cancer therapeutics

3 March 2020

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7 April 2017

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Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

7 April 2017

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Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

7 April 2017

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

7 April 2017

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7 April 2017

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28 September 2017

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Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma

31 May 2018

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Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

31 May 2018

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Dichloromethyl compounds as mechanism-based inactivators of rat liver cytochromes P-450 in vitro.

31 May 2018

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Androgenic deficiency in male rats treated with perfluorodecanoic acid

31 May 2018

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31 May 2018

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Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition.

31 May 2018

1 reference

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U.S. Food and Drug Administration approval: crizotinib for treatment of advanced or metastatic non-small cell lung cancer that is anaplastic lymphoma kinase positive.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671996

Expression parameters of the metabolic pathway genes pyruvate dehydrogenase kinase-1 (PDK-1) and DJ-1/PARK7 in renal cell carcinoma (RCC).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671996

Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671996

Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671996

Coming up for air: HIF-1 and mitochondrial oxygen consumption

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671996

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671996

AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671996

Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4671996

OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells

28 November 2018

1 reference

12 December 2020

Comparison of the metabolic and toxic effects of 2-chloropropionate and dichloroacetate

1 reference

12 December 2020

The interplay between MYC and HIF in the Warburg effect

1 reference

12 December 2020

(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase

1 reference

12 December 2020

Toxicity of Chronic Dichloroacetate

1 reference

12 December 2020

Dichloroacetate, sodium: 3-month oral toxicity studies in rats and dogs

1 reference

12 December 2020

Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase

1 reference

12 December 2020

Identifiers

DOI

10.7150/IJBS.13325

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26681918%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26681918%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

2 references