Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion (Q34473984)

2 August 2017

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion (English)

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2 August 2017

2

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2 June 2020

Justin R. Cross

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2 June 2020

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Craig B Thompson

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2 June 2020

author name string

Ji Zhang

1

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2 June 2020

Sriram Venneti

3

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2 June 2020

Toshimitsu Takagi

5

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2 June 2020

Bhavneet Bhinder

6

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2 June 2020

Hakim Djaballah

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2 June 2020

Masayuki Kanai

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2 June 2020

Emily H Cheng

9

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2 June 2020

Alexander R Judkins

10

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2 June 2020

Bruce Pawel

11

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2 June 2020

Julie Baggs

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2 June 2020

Joshua D Rabinowitz

14

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2 June 2020

Sara Cherry

13

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2 June 2020

publication date

18 September 2014

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2 August 2017

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2 June 2020

volume

56

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2 June 2020

page(s)

205-218

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2 June 2020

issue

2

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Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

2 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Asparaginases: biochemical pharmacology and modes of drug resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Metabolomic analysis and visualization engine for LC-MS data

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Quiescent fibroblasts exhibit high metabolic activity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Glutamine addiction: a new therapeutic target in cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Bidirectional transport of amino acids regulates mTOR and autophagy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Regulated translation initiation controls stress-induced gene expression in mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Congenital lactic acidosis associated with pyruvate carboxylase deficiency. Repository identification No. GM6056.

6 July 2018

1 reference

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Neonatal pyruvate carboxylase deficiency with renal tubular acidosis and cystinuria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

l-Asparaginase resistance in human leukemia—Asparagine synthetase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Glutaminolysis activates Rag-mTORC1 signaling.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224619

Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors.

27 October 2018

1 reference

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Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

27 October 2018

1 reference

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Free amino acids in growing and regressing ascites cell tumors: host resistance and chemical agents.

27 October 2018

1 reference

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Studies on the utilization of asparagine by mouse leukemia cells

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25242145

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2014.08.018

1 reference

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2 June 2020

1 reference

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2 June 2020

1 reference

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