Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs (Q26766039)

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Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs (English)

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regulatory science

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5

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Atsushi Ohtsu

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Yoshihiro Hayakawa

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Manabu Kawada

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Hiroyoshi Nishikawa

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Takahiro Ochiya

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Ryoji Yao

7

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Masahiro Hayashi

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Chieko Kai

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Akira Matsuda

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Tomoki Naoe

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Hideo Saji

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Masataka Sata

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Haruhiko Sugimura

16

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Yuichi Sugiyama

17

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Tatsuro Irimura

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3 April 2019

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189-202

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Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy

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Patient-derived tumour xenografts as models for breast cancer drug development

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28 September 2017

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28 September 2017

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Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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PTEN loss accelerates KrasG12D-induced pancreatic cancer development

28 September 2017

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Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency

28 September 2017

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28 September 2017

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28 September 2017

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Targeting the cancer kinome through polypharmacology

28 September 2017

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Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

28 September 2017

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Pten in stromal fibroblasts suppresses mammary epithelial tumours

28 September 2017

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Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts

28 September 2017

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A mouse model for EML4-ALK-positive lung cancer

28 September 2017

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A history of cancer chemotherapy

28 September 2017

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Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

28 September 2017

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Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice

28 September 2017

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Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis

28 September 2017

1 reference

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Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

28 September 2017

1 reference

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Translation of new cancer treatments from pet dogs to humans

28 September 2017

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Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

28 September 2017

1 reference

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A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

28 September 2017

1 reference

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Ba/F3 cells and their use in kinase drug discovery

28 September 2017

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Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

28 September 2017

1 reference

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Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

28 September 2017

1 reference

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

28 September 2017

1 reference

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Collaboration of Brca1 and Chk2 in tumorigenesis

28 September 2017

1 reference

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Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

28 September 2017

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Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model

28 September 2017

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DNA and its associated processes as targets for cancer therapy

28 September 2017

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Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum

28 September 2017

1 reference

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Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse

28 September 2017

1 reference

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Cloning, expression and tissue distribution of the murine homologue of the melanocyte lineage-specific antigen gp100.

28 September 2017

2 references

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28 September 2017

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product

21 January 2018

1 reference

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Double minutes and homogeneously staining regions: gene amplification in mammalian cells

28 September 2017

1 reference

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Cellular Oncogenes and Multistep Carcinogenesis

28 September 2017

1 reference

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Role of gene and chromosomal mutations in cell transformation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

Use of differentiation-inducing agents in the myelodysplastic syndrome and acute non-lymphocytic leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

Tumor suppressor genes: new prospects for cancer research

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

Transduction and expression of the human carcinoembryonic antigen gene in a murine colon carcinoma cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

Genetic approaches to the study of the molecular basis of human cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

A mouse model of basal-like breast carcinoma with metaplastic elements

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768389

Melanocytes in conditional Rb-/- mice are normal in vivo but exhibit proliferation and pigmentation defects in vitro.

31 May 2018

1 reference

A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis.

21 January 2018

1 reference

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

21 January 2018

1 reference

HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice

21 January 2018

1 reference

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

21 January 2018

1 reference

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

21 January 2018

1 reference

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

21 January 2018

1 reference

Genetic background controls tumor development in PTEN-deficient mice.

21 January 2018

1 reference

A mouse model for endometrioid ovarian cancer arising from the distal oviduct.

21 January 2018

1 reference

Inducible expression of (V600E) Braf using tyrosinase-driven Cre recombinase results in embryonic lethality.

21 January 2018

1 reference

In vivo matrigel migration and angiogenesis assay.

21 January 2018

1 reference

Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice

21 January 2018

1 reference

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance

21 January 2018

1 reference

12 December 2020

In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

1 reference

12 December 2020

Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene

1 reference

12 December 2020

Tumours can act as adjuvants for humoral immunity

1 reference

12 December 2020

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1111/CAS.12857

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26919617%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26919617%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26919617%20AND%20SRC:MED&resulttype=core&format=json