Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene (Q34593929)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20952506%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene (English)

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15 February 2020

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2

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15 February 2020

Julian Carretero

4

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15 February 2020

Yuchuan Wang

8

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15 February 2020

Marzia Capelletti

10

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15 February 2020

Andrew L. Kung

19

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15 February 2020

Kwok Kin Wong

22

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15 February 2020

18

Nathanael S Gray

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15 February 2020

author name string

Zhao Chen

1

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15 February 2020

Xiaohong Tan

3

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15 February 2020

Takeshi Shimamura

5

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15 February 2020

Danan Li

6

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15 February 2020

Chunxiao Xu

7

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15 February 2020

Guillaume O Adelmant

9

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15 February 2020

Hyun Joo Lee

11

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15 February 2020

Scott J Rodig

12

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15 February 2020

Christa Borgman

13

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15 February 2020

Seung-Il Park

14

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15 February 2020

Hyeong Ryul Kim

15

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15 February 2020

Robert Padera

16

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15 February 2020

Jarrod A Marto

17

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15 February 2020

Geoffrey I Shapiro

20

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15 February 2020

Pasi A Jänne

21

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15 February 2020

language of work or name

English

0 references

publication date

15 October 2010

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15 February 2020

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15 February 2020

volume

70

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15 February 2020

page(s)

9827-9836

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15 February 2020

issue

23

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Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors

15 February 2020

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7 July 2018

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Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population

7 July 2018

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Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK

7 July 2018

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7 July 2018

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7 July 2018

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KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

7 July 2018

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

7 July 2018

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Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.

7 July 2018

1 reference

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EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

7 July 2018

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EML4-ALK fusion lung cancer: a rare acquired event

7 July 2018

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Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

7 July 2018

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Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

7 July 2018

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

7 July 2018

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

7 July 2018

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Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

7 July 2018

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Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas

7 July 2018

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Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

7 July 2018

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The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression

7 July 2018

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Inhibitors of the HSP90 molecular chaperone: current status

7 July 2018

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The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

7 July 2018

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V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

7 July 2018

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

7 July 2018

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Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

7 July 2018

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Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

7 July 2018

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

7 July 2018

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Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein

7 July 2018

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

7 July 2018

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7 July 2018

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7 July 2018

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Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway

7 July 2018

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Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells.

7 July 2018

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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

7 July 2018

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Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene.

7 July 2018

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ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer.

27 October 2018

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The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043107

EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043107

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.

27 October 2018

1 reference

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Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.

27 October 2018

1 reference

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An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.

27 October 2018

1 reference

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Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043107

Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043107

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20952506

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-10-1671

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20952506%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20952506%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference