Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease (Q26765782)

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8 March 2020

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Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease (English)

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1 May 2021

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8 March 2020

Renata Santos

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8 March 2020

Cláudio M. Gomes

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8 March 2020

author name string

Joana S Cristóvão

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Renata Santos

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Cláudio M Gomes

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language of work or name

English

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publication date

10 January 2016

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4 November 2019

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8 March 2020

1 May 2021

Oxidative medicine and cellular longevity

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25 April 2019

12 September 2019

12 October 2019

4 November 2019

28 November 2019

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8 March 2020

1 May 2021

2016

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8 March 2020

page(s)

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cites work

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

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Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes

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Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

7 April 2017

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Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

7 April 2017

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Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease

7 April 2017

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S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10

7 April 2017

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Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production

7 April 2017

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RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

7 April 2017

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

7 April 2017

1 reference

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Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain

7 April 2017

1 reference

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

7 April 2017

1 reference

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Neuropathological stageing of Alzheimer-related changes

7 April 2017

1 reference

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Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerability

7 April 2017

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

7 April 2017

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

7 April 2017

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

7 April 2017

1 reference

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Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways

7 April 2017

1 reference

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

7 April 2017

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

7 April 2017

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

7 April 2017

1 reference

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Role of RAGE in Alzheimer's Disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Biological metals and metal-targeting compounds in major neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Alzheimer's disease genetics: from the bench to the clinic

28 September 2017

1 reference

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Amyloid precursor protein and neural development

28 September 2017

1 reference

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Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The intersection of amyloid beta and tau at synapses in Alzheimer's disease

28 September 2017

1 reference

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Genetic markers for diagnosis and pathogenesis of Alzheimer's disease

28 September 2017

1 reference

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Characterization of biometal profiles in neurological disorders.

28 September 2017

1 reference

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S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis

28 September 2017

1 reference

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The complexities of the pathology-pathogenesis relationship in Alzheimer disease

28 September 2017

1 reference

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Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles

28 September 2017

1 reference

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The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

What causes alzheimer's disease?

28 September 2017

1 reference

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Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

A role for tau at the synapse in Alzheimer's disease pathogenesis.

28 September 2017

1 reference

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Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Genetics of familial and sporadic Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of Aβ(1-42) with Cu ions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Functions of S100 proteins.

28 September 2017

1 reference

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Mammalian metallothioneins: properties and functions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

28 September 2017

1 reference

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Copper and oxidative stress in the pathogenesis of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The role of S100a9 in the pathogenesis of Alzheimer's disease: the therapeutic effects of S100a9 knockdown or knockout

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The role of metallobiology and amyloid-β peptides in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Copper promotes the trafficking of the amyloid precursor protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The revitalized tau hypothesis on Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Calcium and cell death signaling in neurodegeneration and aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Alzheimer's disease, metal ions and metal homeostatic therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Copper (II) modulates in vitro aggregation of a tau peptide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Redox reactions of copper complexes formed with different beta-amyloid peptides and their neuropathological [correction of neuropathalogical] relevance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Granular tau oligomers as intermediates of tau filaments

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Molecular anatomy of the postsynaptic density.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Physiological roles for amyloid beta peptides

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The metallobiology of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease

28 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

28 September 2017

12 December 2020

Redox-active iron mediates amyloid-beta toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Neurotrophic protein S100 beta stimulates glial cell proliferation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Comparative techniques for determining cellular iron distribution in brain tissues

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Metal chaperones prevent zinc-mediated cognitive decline

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Calcium regulates the interaction of amyloid precursor protein with Homer3 protein.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Copper prevents amyloid-β(1-42) from forming amyloid fibrils under near-physiological conditions in vitro.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Zinc release of Zn₇-metallothionein-3 induces fibrillar type amyloid-β aggregates

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

High-resolution NMR studies of the zinc-binding site of the Alzheimer's amyloid beta-peptide.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The production of amyloid beta peptide is a critical requirement for the viability of central neurons.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

S100 beta increases levels of beta-amyloid precursor protein and its encoding mRNA in rat neuronal cultures.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Copper, iron and zinc in Alzheimer's disease senile plaques.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Brain iron and ferritin in Parkinson's and Alzheimer's diseases.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Elevated cortical zinc in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Iron: a pathological mediator of Alzheimer disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Characterization of new specific copper chelators as potential drugs for the treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Metal ions differentially influence the aggregation and deposition of Alzheimer's beta-amyloid on a solid template.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Cu(II) binding to monomeric, oligomeric, and fibrillar forms of the Alzheimer's disease amyloid-beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Free Superoxide is an Intermediate in the Production of H2O2 by Copper(I)-Aβ Peptide and O2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Copper enhances APP dimerization and promotes Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Familial Alzheimer's disease-linked presenilin-1 mutation M146V affects store-operated calcium entry: does gain look like loss?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Metallothionein III is reduced in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Metallothionein-3 and neuronal nitric oxide synthase levels in brains from the Tg2576 mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Metallothionein-III antagonizes the neurotoxic and neurotrophic effects of amyloid beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Rapid exchange of metal between Zn(7)-metallothionein-3 and amyloid-β peptide promotes amyloid-related structural changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Elevation of zinc transporter ZnT3 protein in the cerebellar cortex of the AbetaPP/PS1 transgenic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Metal ions as modulators of protein conformation and misfolding in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4736980

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

28 November 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9812178

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents

21 January 2018

1 reference

PubMed

12 December 2020

Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain

1 reference

PubMed

12 December 2020

The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1155/2016/9812178

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26881049%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26881049%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26881049%20AND%20SRC:MED&resulttype=core&format=json