Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer (Q26741846)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27455225%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

review article

4 references

14 September 2020

26 October 2020

30 January 2021

Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer (English)

1 reference

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19 March 2020

1 reference

14 September 2020

antineoplastic resistance

1 reference

epithelial to mesenchymal transition

26 October 2020

1 reference

30 January 2021

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27455225%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

author name string

Bowen Du

series ordinal

1

1 reference

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19 March 2020

language of work or name

English

0 references

publication date

22 July 2016

4 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27455225%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

14 September 2020

26 October 2020

30 January 2021

4 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27455225%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

14 September 2020

26 October 2020

30 January 2021

21

1 reference

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19 March 2020

issue

7

1 reference

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Creative Commons Attribution

19 March 2020

copyright license

3 references

14 September 2020

26 October 2020

30 January 2021

0 references

Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors.

1 reference

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Mechanisms of cancer drug resistance

21 January 2018

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Mechanisms of resistance to cisplatin

21 January 2018

1 reference

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An overview of epithelio-mesenchymal transformation

21 January 2018

1 reference

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The basics of epithelial-mesenchymal transition

21 January 2018

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Epithelial-mesenchymal transitions in development and pathologies

21 January 2018

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Molecular mechanisms of epithelial-mesenchymal transition

21 January 2018

1 reference

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Signaling mechanisms of the epithelial-mesenchymal transition

21 January 2018

1 reference

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Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro

21 January 2018

1 reference

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Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

21 January 2018

1 reference

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Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer

21 January 2018

1 reference

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IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

21 January 2018

1 reference

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Non-Smad TGF-beta signals

21 January 2018

1 reference

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TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

21 January 2018

1 reference

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Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail

21 January 2018

1 reference

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Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Early events in cell adhesion and polarity during epithelial-mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

EMT, the cytoskeleton, and cancer cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Epithelial-mesenchymal transition and drug resistance in breast cancer (Review).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Animal models and the tumor microenvironment: studies of tumor-host symbiosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Twist mediates an aggressive phenotype in human colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

FOXC2 promotes chemoresistance in nasopharyngeal carcinomas via induction of epithelial mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

FOXF2 suppresses the FOXC2-mediated epithelial-mesenchymal transition and multidrug resistance of basal-like breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Identification of human brain tumour initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Molecular requirements for epithelial-mesenchymal transition during tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Role of the MRP1/ABCC1 multidrug transporter protein in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Epithelial-mesenchymal transition and drug resistance: role, molecular mechanisms, and therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

P-glycoproteins and multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A Southwest Oncology Group study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Identification of selective inhibitors of cancer stem cells by high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Consecutive salinomycin treatment reduces doxorubicin resistance of breast tumor cells by diminishing drug efflux pump expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Metformin and reduced risk of cancer in diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Metformin suppresses intestinal polyp growth in ApcMin/+ mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Existing drugs and their application in drug discovery targeting cancer stem cells.

21 January 2018

1 reference

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A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Moscatilin inhibits epithelial-to-mesenchymal transition and sensitizes anoikis in human lung cancer H460 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Inhibitory effects of metformin at low concentration on epithelial-mesenchymal transition of CD44(+)CD117(+) ovarian cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The functions of animal microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

MicroRNAs: target recognition and regulatory functions

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Implication of microRNAs in drug resistance for designing novel cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

MiR-489 regulates chemoresistance in breast cancer via epithelial mesenchymal transition pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Cancer stem cells and chemoresistance: The smartest survives the raid

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Companies waver in efforts to target transforming growth factor beta in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Induction of heart valve lesions by small-molecule ALK5 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Complexities of TGF-β targeted cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Probing the Fifty Shades of EMT in Metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21070965

Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines

21 January 2018

1 reference

12 December 2020

Wnt-dependent regulation of the E-cadherin repressor snail

1 reference

12 December 2020

Epithelial-mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma.

1 reference

12 December 2020

Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status.

1 reference

12 December 2020

Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative

1 reference

12 December 2020

Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma.

1 reference

12 December 2020

EMT and MET in metastasis: where are the cancer stem cells?

1 reference

12 December 2020

EGFR-TKI resistance in NSCLC patients: mechanisms and strategies

1 reference

12 December 2020

Chemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of transforming growth factor β signaling in HCT116 colon cancer cells

1 reference

12 December 2020

Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors.

1 reference

12 December 2020

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

1 reference

12 December 2020

Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment

1 reference

12 December 2020

Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway

1 reference

12 December 2020

Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway.

1 reference

12 December 2020

Transforming growth factor-beta in in vivo resistance

1 reference

12 December 2020

10.3390/MOLECULES21070965

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

2828591

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27455225%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

2828591

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27455225%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

2 references

Consolidated OpenCitations Corpus – April 2017

2828591