Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors. (Q35944737)

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English	Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors.	scientific article

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scholarly article

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18 February 2020

Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors (English)

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18 February 2020

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ChEBI release 2020-05-28

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18 February 2020

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Lei Zhao

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18 February 2020

Shizhou Liu

2

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18 February 2020

Xiaofang Che

3

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18 February 2020

Kezuo Hou

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18 February 2020

Ce Li

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18 February 2020

Ti Wen

7

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18 February 2020

Yibo Fan

8

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18 February 2020

Xuejun Hu

9

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18 February 2020

Yunpeng Liu

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18 February 2020

Xiujuan Qu

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18 February 2020

publication date

30 June 2015

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18 February 2020

International Journal of Molecular Medicine

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18 February 2020

36

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18 February 2020

3

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18 February 2020

645-652

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18 February 2020

Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice

1 reference

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2 October 2017

Cancer statistics, 2014

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2 October 2017

TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis

1 reference

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2 October 2017

Management of non-small-cell lung cancer: recent developments

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2 October 2017

Bufalin, a component in Chansu, inhibits proliferation and invasion of hepatocellular carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

2 October 2017

Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients.

1 reference

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2 October 2017

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling

1 reference

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2 October 2017

Bufalin prevents the migration and invasion of T24 bladder carcinoma cells through the inactivation of matrix metalloproteinases and modulation of tight junctions

1 reference

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2 October 2017

Autocrine regulation of TGF-β1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells

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2 October 2017

Induction of epithelial-mesenchymal transition by transforming growth factor β.

1 reference

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2 October 2017

Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

2 October 2017

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

1 reference

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2 October 2017

Tumor metastasis: molecular insights and evolving paradigms

1 reference

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2 October 2017

Bufalin-inhibited migration and invasion in human osteosarcoma U-2 OS cells is carried out by suppression of the matrix metalloproteinase-2, ERK, and JNK signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

2 October 2017

Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

2 October 2017

Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

2 October 2017

IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells

1 reference

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2 October 2017

PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

2 October 2017

TGF-beta-induced epithelial to mesenchymal transition

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2 October 2017

Non-Smad pathways in TGF-beta signaling

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2 October 2017

TGFbeta in Cancer

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2 October 2017

Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship

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2 October 2017

Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of A549 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

2 October 2017

TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

2 October 2017

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

1 reference

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2 October 2017

The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

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2 October 2017

Epithelial-mesenchymal transitions in tumour progression

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2 October 2017

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

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2 October 2017

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

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2 October 2017

Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB.

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24 September 2018

Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth

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24 September 2018

Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

24 September 2018

Up-regulation of the Cbl family of ubiquitin ligases is involved in ATRA and bufalin-induced cell adhesion but not cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4533784

24 September 2018

WT1 downregulation during K562 cell differentiation and apoptosis induced by bufalin.

1 reference

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24 September 2018

Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26133118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia cells in combination with other inducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/26133118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle arrest and protein kinase modulating effect of bufalin on human leukemia ML1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26133118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3892/IJMM.2015.2268

1 reference

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18 February 2020

1 reference

Europe PubMed Central

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18 February 2020

1 reference

Europe PubMed Central

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18 February 2020

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