Questions and controversies in innate immune research: what is the physiological role of NLRP3? (Q26739753)

title

Questions and controversies in innate immune research: what is the physiological role of NLRP3? (English)

0 references

1

R C Coll

R C

Coll

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27551512%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

2

Laj O'Neill

Laj

O'Neill

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27551512%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

3

K Schroder

K

Schroder

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27551512%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

language of work or name

English

0 references

publication date

2016

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2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27551512%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27551512%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

16019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27551512%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

13 June 2020

copyright license

start time

4 April 2016

1 reference

April 2022 Public Data File from Crossref

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

7 April 2017

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Inflammasomes: mechanism of action, role in disease, and therapeutics

7 April 2017

1 reference

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Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Gout-associated uric acid crystals activate the NALP3 inflammasome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Activation and regulation of the inflammasomes

7 April 2017

1 reference

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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

7 April 2017

1 reference

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

7 April 2017

1 reference

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

7 April 2017

1 reference

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

7 April 2017

1 reference

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Biologic basis for interleukin-1 in disease

7 April 2017

1 reference

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The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

NLRP3 at the interface of metabolism and inflammation.

28 September 2017

1 reference

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Tipping the metabolic scales towards increased longevity in mammals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

28 September 2017

1 reference

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NLR proteins and parasitic disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

NLRPs, microbiota, and gut homeostasis: unravelling the connection.

28 September 2017

1 reference

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Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Inflammasome: cancer's friend or foe?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Subversion of inflammasome activation and pyroptosis by pathogenic bacteria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Treating inflammation by blocking interleukin-1 in humans

28 September 2017

1 reference

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Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging

28 September 2017

1 reference

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Role of caspase-1 in regulation of triglyceride metabolism.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Antimicrobial functions of inflammasomes

28 September 2017

1 reference

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Evolution of inflammatory diseases

28 September 2017

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Caspase-1: is IL-1 just the tip of the ICEberg?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Inflammasome is a central player in the induction of obesity and insulin resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4979470

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

28 September 2017

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Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?

28 September 2017

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Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

28 September 2017

1 reference

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Suppression of food intake during infection: is interleukin-1 involved?

31 May 2018

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Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

31 May 2018

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Crossref

https://api.crossref.org/works/10.1038%2FCDDISCOVERY.2016.19

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1038%2FCDDISCOVERY.2016.19

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

21 January 2018

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Crossref

https://api.crossref.org/works/10.1038%2FCDDISCOVERY.2016.19

Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27551512

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27551512

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDISCOVERY.2016.19

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27551512%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 June 2020

1005577405

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27551512%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

2 references