Tipping the metabolic scales towards increased longevity in mammals (Q38365609)

2 September 2017

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title

Tipping the metabolic scales towards increased longevity in mammals (English)

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2 September 2017

Celine E Riera

1

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PubMed ID

25720959

2 September 2017

Andrew Dillin

series ordinal

2

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2 September 2017

1 March 2015

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2 September 2017

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2 September 2017

17

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2 September 2017

196-203

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2 September 2017

3

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https://scigraph.springernature.com/pub.10.1038/ncb3107

2 September 2017

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Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

21 January 2018

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Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice

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Obesity and Alzheimer's disease: a link between body weight and cognitive function in old age.

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Pten positively regulates brown adipose function, energy expenditure, and longevity

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Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.

21 January 2018

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Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice

21 January 2018

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

21 January 2018

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21 January 2018

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

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The immunosuppressant rapamycin represses human immunodeficiency virus type 1 replication

21 January 2018

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Duration of rapamycin treatment has differential effects on metabolism in mice

21 January 2018

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Overexpression of Atg5 in mice activates autophagy and extends lifespan

21 January 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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The role of mitochondria in aging

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A Morphometric Study of Age-Dependent Changes in Mitochondrial Populations of Mouse Liver and Heart

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Mitochondrial function as a determinant of life span

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Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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PGC1α and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disorders

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

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AMPK and PPARdelta agonists are exercise mimetics

21 January 2018

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In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis

21 January 2018

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Metformin improves healthspan and lifespan in mice

21 January 2018

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

21 January 2018

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

21 January 2018

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Superoxide activates mitochondrial uncoupling proteins

21 January 2018

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Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease.

21 January 2018

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Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

21 January 2018

1 reference

Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis

21 January 2018

1 reference

Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells

21 January 2018

1 reference

Extension of murine life span by overexpression of catalase targeted to mitochondria

21 January 2018

1 reference

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

21 January 2018

1 reference

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

21 January 2018

1 reference

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

21 January 2018

1 reference

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

21 January 2018

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice.

21 January 2018

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The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

21 January 2018

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Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

21 January 2018

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The cell-non-autonomous nature of electron transport chain-mediated longevity

21 January 2018

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Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

21 January 2018

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The mitochondrial unfolded protein response in mammalian physiology

21 January 2018

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A mitochondrial specific stress response in mammalian cells

21 January 2018

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Mitonuclear protein imbalance as a conserved longevity mechanism

21 January 2018

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Early mitochondrial dysfunction in long-lived Mclk1+/- mice

21 January 2018

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PARP-2 regulates SIRT1 expression and whole-body energy expenditure

21 January 2018

1 reference

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

21 January 2018

1 reference

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

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Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

21 January 2018

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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

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Linking mitochondrial bioenergetics to insulin resistance via redox biology

21 January 2018

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Mitochondrial dysfunction and type 2 diabetes

21 January 2018

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Insulin resistance and pathological brain ageing

21 January 2018

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The molecular basis for oxidative stress-induced insulin resistance

21 January 2018

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Reactive oxygen species and the central nervous system

21 January 2018

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PPARγ agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets.

21 January 2018

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Obesity is associated with hypothalamic injury in rodents and humans

21 January 2018

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Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity

21 January 2018

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Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.

21 January 2018

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

21 January 2018

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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

21 January 2018

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Mfn2 modulates the UPR and mitochondrial function via repression of PERK

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

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ER stress-induced inflammation: does it aid or impede disease progression?

21 January 2018

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From endoplasmic-reticulum stress to the inflammatory response

21 January 2018

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Mitochondrial alteration in type 2 diabetes and obesity: an epigenetic link.

21 January 2018

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Chinese agriculture: An experiment for the world

21 January 2018

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Mitochondrial diseases

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12 December 2020

Oxidative capacity and ageing in human muscle

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12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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12 December 2020

Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

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12 December 2020

Hypoinsulinemia of Hypothyroidism

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12 December 2020

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

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12 December 2020

Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity

1 reference

12 December 2020

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

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12 December 2020

The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating Energy Dissipation

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCB3107

1 reference

PubMed ID

25720959

Dimensions Publication ID

2 September 2017

0 references

1 reference

PubMed ID

25720959