Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts (Q24634195)

1

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Cecilia D Blair

2

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Dina A Faddah

3

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Julia E Kieckhaefer

4

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Michelle Olive

5

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Michael R Erdos

6

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Elizabeth G Nabel

Journal of Clinical Investigation

7

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language of work or name

English

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publication date

July 2011

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published in

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volume

121

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page(s)

2833-44

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issue

7

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cites work

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

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7 April 2017

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Phenotype and course of Hutchinson-Gilford progeria syndrome

7 April 2017

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The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

7 April 2017

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Lamin A-dependent nuclear defects in human aging

7 April 2017

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Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody

7 April 2017

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Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita

7 April 2017

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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

7 April 2017

1 reference

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Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

7 April 2017

1 reference

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Extension of life-span by introduction of telomerase into normal human cells

7 April 2017

1 reference

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

7 April 2017

1 reference

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Nuclear lamins: building blocks of nuclear architecture

7 April 2017

1 reference

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Human laminopathies: nuclei gone genetically awry

7 April 2017

1 reference

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Shelterin: the protein complex that shapes and safeguards human telomeres

7 April 2017

1 reference

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Genomic instability in laminopathy-based premature aging

7 April 2017

1 reference

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

7 April 2017

1 reference

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Telomere length regulation

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

The processing pathway of prelamin A

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Telomeres shorten during ageing of human fibroblasts

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Structure and function of telomeres

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.

7 April 2017

1 reference

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Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

27 September 2017

1 reference

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Telomere length in Hutchinson-Gilford progeria syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Nuclear lamins and chromatin: when structure meets function.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Cellular senescence and organismal aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Telomerase, senescence and ageing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Good news in the nuclear envelope: loss of lamin A might be a gain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Mammalian telomeres and telomerase: why they matter for cancer and aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Lamin a truncation in Hutchinson-Gilford progeria.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Mitotic misregulation and human aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Decreased and aberrant nuclear lamin expression in gastrointestinal tract neoplasms

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

A reassessment of the telomere hypothesis of senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Telomeres, telomerase, and aging: origin of the theory

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Alteration of DNA and RNA binding activity of human telomere binding proteins occurs during cellular senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Fibroblast clones from patients with Hutchinson-Gilford progeria can senesce despite the presence of telomerase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223819

Intracellular determinants of cell aging.

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21670498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21670498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI43578

1 reference

release_62ejdnnzzzda3fmf2ofsm7fsue

1784065

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/62ejdnnzzzda3fmf2ofsm7fsue

mapped directly with Wikidata item

24 November 2022

based on heuristic

1784065

1 reference

1 reference

1 reference