Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. (Q33895774)

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English	Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.	scientific article

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30 December 2019

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation (English)

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30 December 2019

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Stephen G. Young

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Loren G Fong

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Margarita Meta

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Shao H Yang

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30 December 2019

Martin O Bergo

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30 December 2019

Julia I Toth

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30 December 2019

Xin Qiao

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30 December 2019

Yan Hu

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30 December 2019

Salemiz Sandoval

6

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30 December 2019

Pravin Bendale

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Michael H Gelb

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12 July 2005

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30 December 2019

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6

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Proceedings of the National Academy of Sciences of the United States of America

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30 December 2019

10291-10296

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30 December 2019

Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development

1 reference

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5 July 2018

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

1 reference

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5 July 2018

New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

1 reference

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5 July 2018

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

1 reference

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5 July 2018

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Life at the edge: the nuclear envelope and human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Head and/or CaaX domain deletions of lamin proteins disrupt preformed lamin A and C but not lamin B structure in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

5 July 2018

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1 reference

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5 July 2018

Production of homozygous mutant ES cells with a single targeting construct

1 reference

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5 July 2018

Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina

1 reference

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5 July 2018

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity

1 reference

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29 October 2018

Novel lamin A/C gene (LMNA) mutations in atypical progeroid syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174929

29 October 2018

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

1 reference

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29 October 2018

The role of isoprenylation in membrane attachment of nuclear lamins. A single point mutation prevents proteolytic cleavage of the lamin A precursor and confers membrane binding properties

1 reference

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29 October 2018

Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16014412

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16014412

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression systems for nuclear lamin proteins: farnesylation in assembly of nuclear lamina

1 reference

https://pubmed.ncbi.nlm.nih.gov/16014412

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse model carrying H222P- Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16014412

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.0504641102

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30 December 2019

2005PNAS..10210291Y

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1 reference

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30 December 2019

1 reference

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