Loop L5 acts as a conformational latch in the mitotic kinesin Eg5 (Q24627077)

1

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Jeremie Vendome

2

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Zoltan Maliga

4

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Carolyn Moores

5

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Steven S Rosenfeld

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

18 February 2011

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published in

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volume

286

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page(s)

5242-53

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issue

7

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cites work

The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5

1 reference

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Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core

7 April 2017

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ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism

7 April 2017

1 reference

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ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

7 April 2017

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9-Angström structure of a microtubule-bound mitotic motor

7 April 2017

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ATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome Movement

7 April 2017

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Switch-based mechanism of kinesin motors

7 April 2017

1 reference

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Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

7 April 2017

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7 April 2017

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Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5

7 April 2017

1 reference

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A structural change in the kinesin motor protein that drives motility

7 April 2017

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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.

7 April 2017

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Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

27 September 2017

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The structure of microtubule motor proteins

27 September 2017

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A kinesin switch I arginine to lysine mutation rescues microtubule function

27 September 2017

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27 September 2017

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Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

27 September 2017

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Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition

21 January 2018

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Docking and rolling, a model of how the mitotic motor Eg5 works

21 January 2018

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New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications

21 January 2018

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KIF1A alternately uses two loops to bind microtubules

21 January 2018

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Mechanism of inhibition of human KSP by ispinesib

21 January 2018

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A pathway of structural changes produced by monastrol binding to Eg5.

21 January 2018

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ATP reorients the neck linker of kinesin in two sequential steps

21 January 2018

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GROMACS 3.0: a package for molecular simulation and trajectory analysis

21 January 2018

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Highly processive microtubule-stimulated ATP hydrolysis by dimeric kinesin head domains

21 January 2018

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Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21148480

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pathway of ATP hydrolysis by monomeric and dimeric kinesin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21148480

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as subtrates for various enzymes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21148480