Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core (Q24598362)

22 June 2017

Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core (English)

1 reference

22 June 2017

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Elizabeth D Kim

1

1 reference

22 June 2017

Rebecca Buckley

2

1 reference

22 June 2017

Sarah Learman

3

1 reference

22 June 2017

Jessica Richard

4

1 reference

22 June 2017

Courtney Parke

5

1 reference

22 June 2017

David K Worthylake

6

1 reference

22 June 2017

Edward J Wojcik

7

1 reference

22 June 2017

Richard A Walker

8

1 reference

22 June 2017

Sunyoung Kim

9

1 reference

22 June 2017

language of work or name

English

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publication date

18 March 2010

1 reference

Journal of Biological Chemistry

22 June 2017

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22 June 2017

285

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22 June 2017

24

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22 June 2017

18650-18661

1 reference

Real-time structural transitions are coupled to chemical steps in ATP hydrolysis by Eg5 kinesin

22 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Monastrol inhibition of the mitotic kinesin Eg5.

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Three myosin V structures delineate essential features of chemo-mechanical transduction

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

9-Angström structure of a microtubule-bound mitotic motor

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Inhibition of a mitotic motor protein: where, how, and conformational consequences

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

A structural state of the myosin V motor without bound nucleotide

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Improved methods for building protein models in electron density maps and the location of errors in these models

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Detergent binding explains anomalous SDS-PAGE migration of membrane proteins

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Data integration in plant biology: the O2PLS method for combined modeling of transcript and metabolite data

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Large conformational changes in a kinesin motor catalyzed by interaction with microtubules

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Finding haplotype tagging SNPs by use of principal components analysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Is allostery an intrinsic property of all dynamic proteins?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a difference FT-IR investigation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

The role of dynamics in allosteric regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

HR22C16: a potent small-molecule probe for the dynamics of cell division

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

What vibrations tell us about proteins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Interactive exploration of microarray gene expression patterns in a reduced dimensional space

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Determination of protein secondary structure by Fourier transform infrared spectroscopy: a critical assessment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881790

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

27 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

Mechanism of inhibition of human KSP by ispinesib

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

Crystal structure of HsEg5 in complex with clinical candidate CK0238273 provides insight into inhibitory mechanism, potency, and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

Ca2+/calmodulin regulation of the Arabidopsis kinesin-like calmodulin-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

Monastrol stabilises an attached low-friction mode of Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

A structural model for actin-induced nucleotide release in myosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

Allostery without conformational change. A plausible model

21 January 2018

1 reference

12 December 2020

Conformational changes in the extrinsic manganese stabilizing protein can occur upon binding to the photosystem II reaction center: an isotope editing and FT-IR study

1 reference

12 December 2020

Resolution-enhanced Fourier transform infrared spectroscopy of enzymes

1 reference

12 December 2020

Evaluation of the secondary structure of apo B-100 in low-density lipoprotein (LDL) by infrared spectroscopy

1 reference

12 December 2020

Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5

1 reference

12 December 2020

Vibrational spectroscopy and conformation of peptides, polypeptides, and proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.092072

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1074/JBC.M109.092072

1 reference

OpenCitations bibliographic resource ID

22 June 2017

2054834

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference