Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor (Q24598030)

2

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W Hoeffken

3

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J E Sadler

4

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P Pereira

5

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R Huber

6

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W Bode

7

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P Fuentes-Prior

Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin

8

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language of work or name

English

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publication date

1 November 2000

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published in

The EMBO Journal

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volume

19

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issue

21

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page(s)

5650-60

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cites work

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Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

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New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK

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Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug

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The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

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Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study

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Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

24 March 2017

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

24 March 2017

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Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

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The coagulation cascade: initiation, maintenance, and regulation

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How the protease thrombin talks to cells

24 March 2017

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From natural to synthetic multisite thrombin inhibitors

27 September 2017

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Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex

27 September 2017

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Thrombin inhibitors as antithrombotic agents: the importance of rapid inhibition

27 September 2017

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A player of many parts: the spotlight falls on thrombin's structure.

27 September 2017

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Molecular mapping of the heparin-binding exosite of thrombin

27 September 2017

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Novel hirudin variants from the leech Hirudinaria manillensis. Amino acid sequence, cDNA cloning and genomic organization

27 September 2017

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Hirudins and the role of thrombin: lessons from leeches

27 September 2017

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Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin

27 September 2017

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Natural protein proteinase inhibitors and their interaction with proteinases

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Primary structure and function of novel O-glycosylated hirudins from the leech Hirudinaria manillensis

27 September 2017

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Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition

27 September 2017

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Binding of hirudin to meizothrombin

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Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms

30 May 2018

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On the isolation of the thrombin inhibitor hirudin.

30 May 2018

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The structures and proteolytic specificities of autolysed human thrombin

30 May 2018

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Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex.

30 May 2018

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Hirudin: amino-terminal residues play a major role in the interaction with thrombin

30 May 2018

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Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin

30 May 2018

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30 May 2018

Anticoagulant thrombins.

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Isolation, sequence analysis, and cloning of haemadin. An anticoagulant peptide from the Indian leech.

28 November 2018

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Multiple active forms of thrombin. IV. Relative activities of meizothrombins

28 November 2018

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12 December 2020

Thrombin, thrombomodulin and TAFI in the molecular link between coagulation and fibrinolysis

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12 December 2020

Bothroalternin, a thrombin inhibitor from the venom of Bothrops alternatus

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12 December 2020

Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101

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12 December 2020

Functional characterization of recombinant human meizothrombin and Meizothrombin(desF1). Thrombomodulin-dependent activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI), platelet aggregation, antithrombin-III inhibition

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12 December 2020

Bothrojaracin: a potent two-site-directed thrombin inhibitor

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12 December 2020

The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution

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12 December 2020

[34] Rotation function calculations with GLRF program

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12 December 2020

The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III

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12 December 2020

Thrombolytic therapy in acute myocardial infarction--selected recent developments

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12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.21.5650

1 reference

1 reference

1 reference

PubMed publication ID

11060016

1 reference