The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment (Q27700069)

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English	The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment	scientific article

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scholarly article

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The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment (English)

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crystal structure

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author name string

W Bode

1

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I Mayr

2

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U Baumann

3

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R Huber

4

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S R Stone

5

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J Hofsteenge

6

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language of work or name

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publication date

November 1989

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The EMBO Journal

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8

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3467-75

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11

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Refined crystal structure of gamma-chymotrypsin at 1.9 A resolution. Comparison with other pancreatic serine proteases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

20 March 2017

Refined 2 A X-ray crystal structure of porcine pancreatic kallikrein A, a specific trypsin-like serine proteinase. Crystallization, structure determination, crystallographic refinement, structure and its comparison with bovine trypsin

1 reference

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20 March 2017

The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor

1 reference

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20 March 2017

Bovine chymotrypsinogen A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 A resolution

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20 March 2017

Structure of alpha-chymotrypsin refined at 1.68 A resolution

1 reference

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20 March 2017

X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor

1 reference

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20 March 2017

The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor

1 reference

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20 March 2017

Structure of native porcine pancreatic elastase at 1.65 A resolutions

1 reference

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20 March 2017

1 reference

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20 March 2017

Primary structure of human prethrombin 2 and alpha-thrombin

1 reference

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20 March 2017

Amino acid sequence of human prothrombin fragments 1 and 2

1 reference

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20 March 2017

Protein inhibitors of proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

7 April 2017

Thrombin specificity

1 reference

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29 September 2017

Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder

1 reference

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29 September 2017

Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

1 reference

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29 September 2017

The oligosaccharide of human thrombin: investigations of functional significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

29 September 2017

Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

29 September 2017

Identification of a thrombin sequence with growth factor activity on macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

29 September 2017

Thrombin-cellular interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

29 September 2017

Human D-Phe-Pro-Arg-CH2-alpha-thrombin crystallization and diffraction data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

29 September 2017

Physical evidence for an apolar binding site near the catalytic center of human α-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

29 September 2017

The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

29 September 2017

Mechanism of action of thrombin on fibrinogen. IV. Further mapping of the active sites of thrombin and trypsin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

2 June 2018

Communication: An x-ray crystallographic study of thrombin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

2 June 2018

The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

2 June 2018

Mechanism of action of thrombin on fibrinogen. Reaction of the N-terminal CNBr fragment from the Aalpha chain of human fibrinogen with bovine thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

2 June 2018

Human alpha-thrombin binding to nonpolymerized fibrin-Sepharose: evidence for an anionic binding region

1 reference

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2 June 2018

The structures and proteolytic specificities of autolysed human thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

2 June 2018

Inhibited thrombins. Interactions with fibrinogen and fibrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

2 June 2018

Thrombin: active-site topography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401503

2 June 2018

A comparison of the heme binding pocket in globins and cytochrome b5

1 reference

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2 June 2018

Inhibition of thrombin and trypsin by tripeptide aldehydes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of the fibrinogen-thrombin reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computer-generated models of blood coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

63 Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional domain of hirudin, a thrombin-specific inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Covalent structures of beta and gamma autolytic derivatives of human alpha-thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proflavin binding within the fibrinopeptide groove adjacent to the catalytic site of human alpha-thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function relationships in human alpha- and gamma-thrombins

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staphylocoagulase-binding region in human prothrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of thrombin with thrombomodulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin interactions with cultured fibroblasts: relationship to mitogenic stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of regions of alpha-thrombin involved in its interaction with hirudin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic competence of human alpha- and gamma-thrombin in the activation of fibrinogen and factor XIII

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymic and nonenzymic properties of human beta-thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of the binding site on fibrin for the secondary binding site of thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic properties of proteolytic derivatives of human alpha-thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation and characterization of proteolyzed forms of human α-thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of sequence-specific antibodies to identify a secondary binding site in thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin binding to the A alpha-, B beta-, and gamma-chains of fibrinogen and to their remnants contained in fragment E

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hirudin-binding site of human alpha-thrombin. Identification of lysyl residues which participate in the combining site of hirudin-thrombin complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-resolution NMR studies of fibrinogen-like peptides in solution: structural basis for the bleeding disorder caused by a single mutation of Gly(12) to Val(12) in the A alpha chain of human fibrinogen Rouen

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human thrombin: partial primary structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exo-site affinity labeling of human thrombins. Similar labeling on the A chain and B chain/fragments of clotting alpha- and nonclotting gamma/beta-thrombins

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D-PHE-PRO-ARGCH2Cl-A selective affinity label for thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2583108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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