Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms (Q42842320)

8 November 2017

Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms (English)

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8 November 2017

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Priestle JP

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8 November 2017

Rahuel J

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8 November 2017

Rink H

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8 November 2017

Tones M

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8 November 2017

Grütter MG

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8 November 2017

1 October 1993

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8 November 2017

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8 November 2017

2

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8 November 2017

10

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8 November 2017

1630-1642

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Crystallographic R factor refinement by molecular dynamics

8 November 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

On the size of the active site in proteases. I. Papain

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Kinetics of the inhibition of thrombin by hirudin.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Interaction of site specific hirudin variants with alpha-thrombin.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Conformation of recombinant desulfatohirudin in aqueous solution determined by nuclear magnetic resonance

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

The structure of a complex of recombinant hirudin and human alpha-thrombin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Refined structure of the hirudin-thrombin complex

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Characterization of the interactions of a bifunctional inhibitor with alpha-thrombin by molecular modelling and peptide synthesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

The interaction of thrombin with fibrinogen. A structural basis for its specificity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Electrostatic interactions in the association of proteins: an analysis of the thrombin-hirudin complex

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2142260

Ionic interactions in the formation of the thrombin-hirudin complex

27 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FPRO.5560021009

21 January 2018

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12 December 2020

Role of interactions involving C-terminal nonpolar residues of hirudin in the formation of the thrombin-hirudin complex

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12 December 2020

Anticoagulant activity of synthetic hirudin peptides

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12 December 2020

Human alpha- to zeta-thrombin cleavage occurs with neutrophil cathepsin G or chymotrypsin while fibrinogen clotting activity is retained

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12 December 2020

Structure-function relationships of hirulog peptide interactions with thrombin

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12 December 2020

The use of sequence-specific antibodies to identify a secondary binding site in thrombin

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12 December 2020

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12 December 2020

Distinct binding sites of Ala48-hirudin1-47 and Ala48-hirudin48-65 on alpha-thrombin

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12 December 2020

The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution

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12 December 2020

Bifunctional thrombin inhibitors based on the sequence of hirudin45-65

1 reference

12 December 2020

Identifiers

DOI

10.1002/PRO.5560021009

1 reference

8 November 2017

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8 November 2017

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