Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) (Q24550960)

4

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Christopher J. Schofield

17

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Emily Flashman

object named as

Emily Flashman

3

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Neil J Oldham

object named as

Neil J Oldham

8

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Michael A McDonough

object named as

Michael A McDonough

1

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author name string

Vivian Li

2

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Christopher Mohr

5

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Benoît M R Liénard

6

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James Zondlo

7

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Ian J Clifton

9

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Jeffrey Lewis

10

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Luke A McNeill

11

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Robert J M Kurzeja

12

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Kirsty S Hewitson

13

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Evelyn Yang

14

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Steven Jordan

15

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Rashid S Syed

Proceedings of the National Academy of Sciences of the United States of America

16

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language of work or name

English

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publication date

27 June 2006

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published in

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volume

103

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issue

26

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page(s)

9814-9

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cites work

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

24 March 2017

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

24 March 2017

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A conserved family of prolyl-4-hydroxylases that modify HIF

24 March 2017

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

24 March 2017

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau

24 March 2017

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Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

24 March 2017

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Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases

24 March 2017

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Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)

24 March 2017

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Structure of a cephalosporin synthase

24 March 2017

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Coot: model-building tools for molecular graphics

24 March 2017

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

24 March 2017

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Automated MAD and MIR structure solution

24 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

24 March 2017

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24 March 2017

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Histone demethylation by a family of JmjC domain-containing proteins

22 April 2017

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

24 March 2017

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Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

24 March 2017

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Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

24 March 2017

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

24 March 2017

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FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

24 March 2017

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Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

24 March 2017

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

24 March 2017

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AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

24 March 2017

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Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

7 April 2017

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The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing

27 September 2017

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Dioxygenases as O2-dependent regulators of the hypoxic response pathway

27 September 2017

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Signalling hypoxia by HIF hydroxylases

27 September 2017

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Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme.

27 September 2017

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Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer

27 September 2017

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Molecular basis of Refsum disease: sequence variations in phytanoyl-CoA hydroxylase (PHYH) and the PTS2 receptor (PEX7).

27 September 2017

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The role of iron and 2-oxoglutarate oxygenases in signalling

27 September 2017

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Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis

27 September 2017

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Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

27 September 2017

1 reference

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Depicting topology and handedness in jellyroll structures.

27 September 2017

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A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases

30 May 2018

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2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

21 January 2018

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O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase

21 January 2018

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Selective inhibition of factor inhibiting hypoxia-inducible factor

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0601283103

The Skp1 prolyl hydroxylase from Dictyostelium is related to the hypoxia-inducible factor-alpha class of animal prolyl 4-hydroxylases

21 January 2018

1 reference

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Inactivation of 1-Aminocyclopropane-1-carboxylate Oxidase Involves Oxidative Modifications†

21 January 2018

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The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids

21 January 2018

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Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives

28 November 2018

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