The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing (Q36253857)

13 August 2017

title

The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing (English)

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13 August 2017

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1

William G Kaelin

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13 August 2017

publication date

30 August 2005

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Biochemical and Biophysical Research Communications

13 August 2017

language of work or name

English

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published in

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13 August 2017

volume

338

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13 August 2017

issue

1

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13 August 2017

page(s)

627-638

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publication type of scholarly work

13 August 2017

review article

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.

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Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

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Sumoylation increases HIF-1alpha stability and its transcriptional activity

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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12 October 2022

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The von Hippel-Lindau tumor suppressor gene and kidney cancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

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https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Polycythemia: mechanisms and management

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

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Analysis of ARD1 function in hypoxia response using retroviral RNA interference

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Selective inhibition of factor inhibiting hypoxia-inducible factor

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Proline hydroxylation and gene expression

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

von Hippel-Lindau Disease

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Molecular basis of the VHL hereditary cancer syndrome

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https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Oxygen sensing by HIF hydroxylases

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Identification of the von Hippel-Lindau disease tumor suppressor gene

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Über eine sehr seltene Erkrankung der Netzhaut

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

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12 October 2022

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

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Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway

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12 October 2022

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

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12 October 2022

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Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

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12 October 2022

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

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12 October 2022

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Pheochromocytoma: the expanding genetic differential diagnosis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Treatment of von Hippel-Lindau retinal hemangioblastoma by the vascular endothelial growth factor receptor inhibitor SU5416 is more effective for associated macular edema than for hemangioblastomas.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

von Hippel-Lindau tumor suppressor: not only HIF's executioner

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The von Hippel-Lindau Gene Product Inhibits Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Renal Cell Carcinoma by Blocking Protein Kinase C Pathways

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Frequent overexpression of vascular endothelial growth factor gene in human renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Activation of Sp1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor Transcription Requires Specific Interaction with Protein Kinase C ζ

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Induction of angiogenesis in a mouse model using engineered transcription factors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

ZUR FRAGE DER ANGIOMATOSIS RETINae UND IHRER HIRNKOMPLIKATIONEN

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Putative Control of Angiogenesis in Hemangioblastomas by the von Hippel-Lindau Tumor Suppressor Gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Suppression of tumor growth through disruption of hypoxia-inducible transcription

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Expression of Vascular Endothelial Growth Factor in Capillary Hemangioblastoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Chat in the trophic web: NGF activates Ret by inter-RTK signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Accumulation of HIF-1alpha under the influence of nitric oxide.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Role of VHL gene mutation in human cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Expression of growth factors and growth factor receptors in capillary hemangioblastoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Loss of heterozygosity on the short arm of chromosome 3 in sporadic, von hippel‐lindau disease‐associated, and familial pheochromocytoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.BBRC.2005.08.165

Identifiers

DOI

10.1016/J.BBRC.2005.08.165

1 reference

13 August 2017

1 reference