Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway (Q24550898)

2

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H Yamamoto

3

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Y Furukawa

4

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S Shimada

5

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Y Nakamura

6

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A Kikuchi

7

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K Miyazono

8

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M Kato

Molecular and Cellular Biology

9

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language of work or name

English

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publication date

August 2001

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published in

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volume

21

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page(s)

5132-41

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issue

15

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cites work

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GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

24 March 2017

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Structural basis of Smad2 recognition by the Smad anchor for receptor activation

24 March 2017

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DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

24 March 2017

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TGF-beta signal transduction

24 March 2017

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

24 March 2017

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Wnt signaling and cancer

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

24 March 2017

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TGF-beta signaling by Smad proteins

24 March 2017

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24 March 2017

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Importin beta mediates nuclear translocation of Smad 3

27 September 2017

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

24 March 2017

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Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction

24 March 2017

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Modulation of Wnt signaling by Axin and Axil

24 March 2017

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Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation

24 March 2017

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Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

24 March 2017

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Smads: transcriptional activators of TGF-beta responses

24 March 2017

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

24 March 2017

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

24 March 2017

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24 March 2017

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Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

24 March 2017

1 reference

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Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos

24 March 2017

1 reference

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Mechanisms of Wnt signaling in development

24 March 2017

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Linking colorectal cancer to Wnt signaling

7 April 2017

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Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

7 April 2017

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Wnt/beta-catenin signaling

27 September 2017

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Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

27 September 2017

1 reference

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Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter

27 September 2017

1 reference

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Microtubule binding to Smads may regulate TGF beta activity

27 September 2017

1 reference

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Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways

27 September 2017

1 reference

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Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

Axin prevents Wnt-3a-induced accumulation of beta-catenin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-beta signals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87238

Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11438668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of Smad proteins in human colorectal cancer.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11438668