Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy (Q24323790)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1990565

Heat shock protein 90 alpha family class B member 1

1 reference

Cell division cycle 37, HSP90 cochaperone

1 reference

Autophagy related 13

1 reference

Cell division cycle 37

1 reference

Heat shock protein 90 alpha (cytosolic), class B member 1

1 reference

Unc-51 like kinase 1

1 reference

Autophagy related 13

1 reference

author

Mondira Kundu

19

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Kelly McCastlain

Kelly McCastlain

6

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Do-Hyung Kim

Do-Hyung Kim

14

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Richard J. Youle

16

Richard J Youle

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Craig B. Thompson

15

Craig B Thompson

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author name string

Joung Hyuck Joo

1

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Frank C Dorsey

2

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Aashish Joshi

3

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Kristin M Hennessy-Walters

4

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Kristie L Rose

5

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Ji Zhang

7

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Rekha Iyengar

8

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Chang Hwa Jung

9

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Der-Fen Suen

10

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Meredith A Steeves

11

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Chia-Ying Yang

12

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Stephanie M Prater

13

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Paul A Ney

17

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John L Cleveland

Network organization of the human autophagy system

18

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language of work or name

English

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publication date

19 August 2011

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published in

Molecular Cell

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volume

43

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issue

4

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page(s)

572-85

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cites work

1 reference

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Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

19 March 2017

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

19 March 2017

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

19 March 2017

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The IKK complex contributes to the induction of autophagy

19 March 2017

1 reference

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

19 March 2017

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

19 March 2017

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

19 March 2017

1 reference

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Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

19 March 2017

1 reference

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siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

19 March 2017

1 reference

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Selective degradation of mitochondria by mitophagy

19 March 2017

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19 March 2017

1 reference

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy

19 March 2017

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VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

19 March 2017

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19 March 2017

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

19 March 2017

1 reference

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The role of the Atg1/ULK1 complex in autophagy regulation

7 April 2017

1 reference

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

7 April 2017

1 reference

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Structure and mechanism of the Hsp90 molecular chaperone machinery

7 April 2017

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Mapping the phosphorylation sites of Ulk1.

27 September 2017

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27 September 2017

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Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

27 September 2017

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Characterization of PINK1 processing, stability, and subcellular localization

27 September 2017

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27 September 2017

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Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.

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Hsp90 inhibition decreases mitochondrial protein turnover

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29 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21855797

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12 December 2020

based on heuristic

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2011.06.018

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2011.06.018

1 reference

1647181

1647181

1 reference

1 reference

1 reference