Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells (Q24318292)

negative regulation of protein kinase B signaling

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Ian A Prior

3

0 references

Michael J. Clague

object named as

Michael J Clague

series ordinal

2

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author name string

Jasminka Omerovic

series ordinal

1

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language of work or name

English

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publication date

15 February 2010

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number of pages

8

1 reference

An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis

inferred from page(s)

published in

Biochemical Journal

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volume

426

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issue

1

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page(s)

65-72

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cites work

1 reference

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Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases

19 March 2017

1 reference

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Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase

19 March 2017

1 reference

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The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase

19 March 2017

1 reference

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Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1

19 March 2017

1 reference

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Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1

19 March 2017

1 reference

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Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase

19 March 2017

1 reference

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

Protein tyrosine phosphatases in the human genome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

Ras oncogenes: split personalities

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

7 April 2017

1 reference

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BRAF mutation predicts sensitivity to MEK inhibition

7 April 2017

1 reference

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

7 April 2017

1 reference

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Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo

27 September 2017

1 reference

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PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

Tenets of PTEN tumor suppression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

Ras isoform abundance and signalling in human cancer cell lines.

27 September 2017

1 reference

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Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.

27 September 2017

1 reference

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Phosphatase and feedback regulation of Raf-1 signaling

27 September 2017

1 reference

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Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration

27 September 2017

1 reference

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Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.

27 September 2017

1 reference

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Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer

27 September 2017

1 reference

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Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351670

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

30 May 2018

1 reference

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Biological properties of human c-Ha-ras1 genes mutated at codon 12.

30 May 2018

1 reference

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Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

30 May 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091413

Point mutants of c-raf-1 RBD with elevated binding to v-Ha-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091413

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091413

Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091413

LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091413

A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using one-step polymerase chain reaction/restriction fragment length polymorphism analysis

21 January 2018

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12 December 2020

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

1 reference

12 December 2020

Transforming growth factor alpha activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations

1 reference

12 December 2020

The differential effects of mutant p53 alleles on advanced murine lung cancer

1 reference

12 December 2020