Epidermal Growth Factor Receptor and the Adaptor Protein p52Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase (Q24522441)

21 June 2017

title

Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase (English)

1 reference

21 June 2017

Epidermal Growth Factor Receptor and the Adaptor Protein p52Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase (English)

1 reference

Crossref

https://api.crossref.org/works/10.1128/MCB.18.3.1622

signal transducing adaptor protein

10 December 2024

main subject

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

vesicular transport adaptor proteins

10 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

10 December 2024

2

A. M. Bennett

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

10 December 2024

author name string

T. Tiganis

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

10 December 2024

K. S. Ravichandran

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

10 December 2024

N. K. Tonks

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

10 December 2024

publication date

1 March 1998

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21 June 2017

March 1998

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9488479

https://europepmc.org/articles/pmc108877?pdf=render

10 December 2024

language of work or name

English

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work available at URL

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

http://mcb.asm.org/cgi/content/abstract/18/3/1622

10 December 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

https://europepmc.org/articles/PMC108877

10 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

https://europepmc.org/articles/PMC108877?pdf=render

10 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9488479

https://journals.asm.org/doi/pdf/10.1128/MCB.18.3.1622

10 December 2024

1 reference

Crossref

https://api.crossref.org/works/10.1128/MCB.18.3.1622

https://www.tandfonline.com/doi/pdf/10.1128/MCB.18.3.1622

10 December 2024

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Crossref

https://api.crossref.org/works/10.1128/MCB.18.3.1622

Molecular and Cellular Biology

10 December 2024

published in

1 reference

21 June 2017

volume

18

1 reference

21 June 2017

issue

3

1 reference

21 June 2017

page(s)

1622-1634

1 reference

Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

21 June 2017

cites work

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24 March 2017

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The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

24 March 2017

1 reference

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24 March 2017

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Substrate specificity of the protein tyrosine phosphatases

24 March 2017

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COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus

24 March 2017

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The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

24 March 2017

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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

24 March 2017

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cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family

24 March 2017

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Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B

24 March 2017

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24 March 2017

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The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

24 March 2017

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Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase

24 March 2017

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

24 March 2017

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Nuclear localization and regulation of erk- and rsk-encoded protein kinases

24 March 2017

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

24 March 2017

1 reference

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Protein modules and signalling networks

24 March 2017

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Rapid and efficient site-specific mutagenesis without phenotypic selection

24 March 2017

1 reference

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Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97

24 March 2017

1 reference

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Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

24 March 2017

1 reference

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

24 March 2017

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

24 March 2017

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

24 March 2017

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Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes

24 March 2017

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Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP

24 March 2017

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A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3

24 March 2017

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Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins

24 March 2017

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Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

24 March 2017

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

24 March 2017

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

7 April 2017

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7 April 2017

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

7 April 2017

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Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

7 April 2017

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7 April 2017

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27 September 2017

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Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis

27 September 2017

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Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

27 September 2017

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27 September 2017

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Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

27 September 2017

1 reference

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Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase

27 September 2017

1 reference

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RETRACTED: 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity

27 September 2017

1 reference

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Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.

27 September 2017

1 reference

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The signaling pathway coupling epidermal growth factor receptors to activation of p21ras

27 September 2017

1 reference

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Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108877

Synthesis of epidermal growth factor receptor in human A431 cells. Glycosylation-dependent acquisition of ligand binding activity occurs post-translationally in the endoplasmic reticulum.

27 September 2017

1 reference

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Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites

27 September 2017

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Characterization of the major protein-tyrosine-phosphatases of human placenta.

27 September 2017

1 reference

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Purification of the major protein-tyrosine-phosphatases of human placenta

27 September 2017

1 reference

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Expression of a human T-cell protein-tyrosine-phosphatase in baby hamster kidney cells

27 September 2017

1 reference

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A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

27 September 2017

1 reference

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Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108877

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

27 September 2017

1 reference

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Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

30 May 2018

1 reference

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Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine

30 May 2018

1 reference

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Cell transformation potential of a HER2 transmembrane domain deletion mutant retained in the endoplasmic reticulum

30 May 2018

1 reference

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Altered subcellular location of an activated and tumour-associated epidermal growth factor receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108877

Protein tyrosine phosphatases and the control of cellular signaling responses

28 July 2018

1 reference

12 December 2020

Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

1 reference

12 December 2020

Activation of transcription via AP-1 or CREB regulatory sites is blocked by protein tyrosine phosphatases

1 reference

12 December 2020

Specificity of T-cell protein tyrosine phosphatase toward phosphorylated synthetic peptides

1 reference

12 December 2020

Acidic residues are involved in substrate recognition by two soluble protein tyrosine phosphatases, PTP-5 and rrbPTP-1

1 reference

12 December 2020

Identifiers

1 reference

National Center for Biotechnology Information

21 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9488479

10 December 2024

1 reference