Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor (Q24306866)

2

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A Grönberg

3

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L Girnita

4

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M Ståhle

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase

5

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language of work or name

English

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publication date

19 January 2012

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published in

Oncogene

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volume

31

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issue

3

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page(s)

352-65

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cites work

1 reference

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LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells

19 March 2017

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Inflammation and cancer: back to Virchow?

19 March 2017

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Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis

19 March 2017

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Cathelicidins, multifunctional peptides of the innate immunity

19 March 2017

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Structural features and biological activities of the cathelicidin-derived antimicrobial peptides

19 March 2017

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Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family

19 March 2017

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Insulin and insulin-like growth factor signalling in neoplasia

19 March 2017

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Beta-arrestins and cell signaling

7 April 2017

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Teaching old receptors new tricks: biasing seven-transmembrane receptors

7 April 2017

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Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma

27 September 2017

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Aberrant intracellular IGF-1R beta-subunit makes receptor knockout cells (IGF1R-/-) susceptible to oncogenic transformation.

27 September 2017

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The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells.

27 September 2017

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Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer

27 September 2017

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The insulin receptor substrate-1: a biomarker for cancer?

27 September 2017

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Tumors sound the alarmin(s).

27 September 2017

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Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth

27 September 2017

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Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival

27 September 2017

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Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion

27 September 2017

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Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer

27 September 2017

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The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells

27 September 2017

1 reference

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Beta-arrestin-biased ligands at seven-transmembrane receptors

27 September 2017

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Antimicrobial peptides: natural effectors of the innate immune system

27 September 2017

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Receptor tyrosine kinases: mechanisms of activation and signaling

27 September 2017

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Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression

27 September 2017

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The role of the IGF system in cancer growth and metastasis: overview and recent insights

27 September 2017

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Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment

27 September 2017

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The insulin-like growth factor-I receptor as a target for cancer therapy

27 September 2017

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Role of insulin-like growth factor 1 receptor signalling in cancer

27 September 2017

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Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells.

27 September 2017

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The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

27 September 2017

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The IGF‐1 receptor in cancer biology

27 September 2017

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Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

27 September 2017

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An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

27 September 2017

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The insulin-like growth factor system and cancer

27 September 2017

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Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase.

27 September 2017

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The contradictions of the insulin-like growth factor 1 receptor

27 September 2017

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Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.

27 September 2017

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Structure and function of the type 1 insulin-like growth factor receptor.

27 September 2017

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Domains of the insulin-like growth factor I receptor required for the activation of extracellular signal-regulated kinases

27 September 2017

1 reference

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Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils

27 September 2017

1 reference

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Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

27 September 2017

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The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

27 September 2017

1 reference

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Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.

30 May 2018

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The human antimicrobial peptide LL-37 suppresses apoptosis in keratinocytes

30 May 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.239

A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.239

Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

21 January 2018

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Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.239

Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.239

Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.239

Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target

21 January 2018

1 reference

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A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

29 November 2018

1 reference

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The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells

29 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.239

Structural features and biological activities of the cathelicidin-derived antimicrobial peptides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.239

The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.239

The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.239

The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.239

Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.239

Inhibition of N-linked glycosylation down-regulates insulin-like growth factor-1 receptor at the cell surface and kills Ewing's sarcoma cells: therapeutic implications

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21685939

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1038/ONC.2011.239

Identifiers

DOI

10.1038/ONC.2011.239

1 reference

Dimensions Publication ID

2597731

1042790825

0 references

2597731

1 reference

1 reference

1 reference