Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome (Q33912989)

30 July 2017

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome (English)

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30 July 2017

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H M Beere

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B B Wolf

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K Cain

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D D Mosser

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A Mahboubi

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T Kuwana

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P Tailor

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R I Morimoto

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G M Cohen

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D R Green

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language of work or name

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1 August 2000

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2

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469-475

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8

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https://scigraph.springernature.com/pub.10.1038/35019501

30 July 2017

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cites work

Suicidal tendencies: apoptotic cell death by caspase family proteinases

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7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

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7 January 2021

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

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7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

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7 January 2021

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

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7 January 2021

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

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7 January 2021

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

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7 January 2021

The heat-shock proteins

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7 January 2021

Protein folding in the cell

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7 January 2021

The role of heat-shock proteins in thermotolerance

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7 January 2021

The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins

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7 January 2021

Expression of human HSP70 during the synthetic phase of the cell cycle

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7 January 2021

Heat shock proteins: regulators of stress response and apoptosis

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7 January 2021

Escaping cell death: survival proteins in cancer

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7 January 2021

Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.

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7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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7 January 2021

Caspase-9 can be activated without proteolytic processing

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7 January 2021

Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9

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7 January 2021

Thermotolerance and heat shock proteins in mammalian cells

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7 January 2021

Induced thermotolerance to apoptosis in a human T lymphocyte cell line

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7 January 2021

Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis

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7 January 2021

Heat shock proteins increase resistance to apoptosis.

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7 January 2021

Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release

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7 January 2021

Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis

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7 January 2021

Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.

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7 January 2021

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

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7 January 2021

Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance

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7 January 2021

Acquired thermotolerance following heat shock protein synthesis prevents impairment of mitochondrial ATPase activity at elevated temperatures in Saccharomyces cerevisiae

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7 January 2021

Mitochondria are selective targets for the protective effects of heat shock against oxidative injury

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7 January 2021

Induction of apoptosis in fibroblasts by c-myc protein

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7 January 2021

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

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7 January 2021

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

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7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

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7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

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7 January 2021

Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis

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7 January 2021

Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.

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7 January 2021

Caspase-9 and APAF-1 form an active holoenzyme

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7 January 2021

Identifiers

DOI

10.1038/35019501

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Dimensions Publication ID

30 July 2017

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