The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity (Q24303868)

Egl-9 family hypoxia inducible factor 1

1 reference

Ajuba LIM protein

1 reference

WT1 interacting protein

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LIM domains containing 1

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negative regulation of transcription, DNA-templated

1 reference

Katherine S Bridge

2

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Victoria James

Victoria James

3

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Yunfeng Feng

Yunfeng Feng

Dumitru Constantin-Teodosiu

7

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Dumitru Constantin-Teodosiu

8

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Peter J. Ratcliffe

Peter J Ratcliffe

12

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author name string

Daniel E Foxler

1

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Thomas M Webb

4

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Maureen Mee

5

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Sybil C K Wong

6

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Thorgunnur Eyfjord Petursdottir

9

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Johannes Bjornsson

10

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Sigurdur Ingvarsson

11

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Gregory D Longmore

13

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Tyson V Sharp

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

14

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language of work or name

English

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publication date

February 2012

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published in

Nature Cell Biology

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volume

14

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issue

2

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page(s)

201-8

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cites work

1 reference

A conserved family of prolyl-4-hydroxylases that modify HIF

20 April 2017

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

20 April 2017

1 reference

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

20 April 2017

1 reference

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

20 April 2017

1 reference

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

20 April 2017

1 reference

LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription

20 April 2017

1 reference

The LIM domain: from the cytoskeleton to the nucleus

20 April 2017

1 reference

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

20 April 2017

1 reference

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

20 April 2017

1 reference

Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers

20 April 2017

1 reference

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

20 April 2017

1 reference

The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex

20 April 2017

1 reference

Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor

20 April 2017

1 reference

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

20 April 2017

1 reference

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

20 April 2017

1 reference

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

20 April 2017

1 reference

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

20 April 2017

1 reference

Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus

20 April 2017

1 reference

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

20 April 2017

1 reference

The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development

20 April 2017

1 reference

The LIM domain is a modular protein-binding interface

21 January 2018

1 reference

The role of hypoxia-inducible factors in tumorigenesis.

21 January 2018

1 reference

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

21 January 2018

1 reference

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

21 January 2018

1 reference

A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi.

21 January 2018

1 reference

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

21 January 2018

1 reference

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis

21 January 2018

1 reference

SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation

21 January 2018

1 reference

Signaling angiogenesis via p42/p44 MAP kinase and hypoxia

21 January 2018

1 reference

Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

21 January 2018

1 reference

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

1 reference

MCM proteins are negative regulators of hypoxia-inducible factor 1.

21 January 2018

1 reference

Siah: new players in the cellular response to hypoxia

21 January 2018

1 reference

Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.

21 January 2018

1 reference

K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function

21 January 2018

1 reference

Identification of human microRNA targets from isolated argonaute protein complexes

21 January 2018

1 reference

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22286099