Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15 (Q24301975)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23104097%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15 (English)

1 reference

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interleukin-15 receptor complex

16 February 2020

main subject

1 reference

Gene Ontology release 2020-05-02

1 reference

1

1 reference

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16 February 2020

Engin Özkan

11

1 reference

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16 February 2020

Ignacio Moraga

9

1 reference

ORCID Public Data File 2021

author name string

Jian-Xin Lin

2

1 reference

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16 February 2020

Dan Feng

3

1 reference

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16 February 2020

Suman Mitra

4

1 reference

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16 February 2020

Mathias Rickert

5

1 reference

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16 February 2020

Gregory R Bowman

6

1 reference

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16 February 2020

Vijay S Pande

7

1 reference

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16 February 2020

Peng Li

8

1 reference

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16 February 2020

Rosanne Spolski

10

1 reference

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16 February 2020

Warren J Leonard

12

1 reference

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16 February 2020

K Christopher Garcia

13

1 reference

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16 February 2020

language of work or name

English

0 references

publication date

28 October 2012

1 reference

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16 February 2020

1 reference

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16 February 2020

volume

13

1 reference

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16 February 2020

issue

12

1 reference

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16 February 2020

page(s)

1187-1195

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Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

16 February 2020

cites work

1 reference

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IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

19 March 2017

1 reference

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Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

19 March 2017

1 reference

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Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins

19 March 2017

1 reference

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Efficiency of signalling through cytokine receptors depends critically on receptor orientation

19 March 2017

1 reference

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Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor

19 March 2017

1 reference

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Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans

19 March 2017

1 reference

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Potent small-molecule binding to a dynamic hot spot on IL-2

19 March 2017

1 reference

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Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130

19 March 2017

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GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

19 March 2017

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Inference of macromolecular assemblies from crystalline state

19 March 2017

1 reference

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HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

19 March 2017

1 reference

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Coot: model-building tools for molecular graphics

19 March 2017

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PHENIX: building new software for automated crystallographic structure determination

19 March 2017

2 references

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19 March 2017

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors

22 April 2017

2 references

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19 March 2017

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IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501574

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

19 March 2017

1 reference

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Canonical sampling through velocity rescaling

7 April 2017

1 reference

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Lysine methylation as a routine rescue strategy for protein crystallization

7 April 2017

1 reference

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IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood

7 April 2017

1 reference

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The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development

27 September 2017

1 reference

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A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy

27 September 2017

1 reference

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Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

27 September 2017

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Network models for molecular kinetics and their initial applications to human health

27 September 2017

1 reference

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RNA-Seq analysis to capture the transcriptome landscape of a single cell

27 September 2017

1 reference

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Trans-presentation: a novel mechanism regulating IL-15 delivery and responses

27 September 2017

1 reference

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Progress and challenges in the automated construction of Markov state models for full protein systems

27 September 2017

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High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer

27 September 2017

1 reference

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New insights into the regulation of T cells by gamma(c) family cytokines

27 September 2017

1 reference

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Using generalized ensemble simulations and Markov state models to identify conformational states

27 September 2017

1 reference

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Transition networks for modeling the kinetics of conformational change in macromolecules

27 September 2017

1 reference

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Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.

27 September 2017

1 reference

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The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

27 September 2017

1 reference

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Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

27 September 2017

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Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling

27 September 2017

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IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

27 September 2017

1 reference

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IL-2 and IL-15 exhibit opposing effects on Fas mediated apoptosis.

27 September 2017

1 reference

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Signaling T-cell survival and death by IL-2 and IL-15.

27 September 2017

1 reference

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IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

27 September 2017

1 reference

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Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling

27 September 2017

1 reference

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Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor

27 September 2017

1 reference

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Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity.

27 September 2017

1 reference

Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions. Phospholipase D-derived diacylglycerol does not activate protein kinase C in porcine aortic endothelial cells

21 January 2018

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Thermodynamic analysis of degenerate recognition by the NKG2D immunoreceptor: not induced fit but rigid adaptation

21 January 2018

1 reference

P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.

21 January 2018

1 reference

Elucidation of the Interleukin-15 Binding Site on Its Alpha Receptor by NMR

21 January 2018

1 reference

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

Ligand binding kinetics of IL-2 and IL-15 to heteromers formed by extracellular domains of the three IL-2 receptor subunits

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23104097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential regulation of T-cell growth by IL-2 and IL-15

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23104097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The structure of interleukin-2 complexed with its alpha receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23104097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.2449

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23104097%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23104097%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23104097%20AND%20SRC:MED&resulttype=core&format=json