Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network (Q24301939)

Par-3 family cell polarity regulator

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Par-6 family cell polarity regulator beta

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sequestosome 1

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Deleted in malignant brain tumors 1

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epithelial cell differentiation

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author

Gerard Drewes

5

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Bernhard Kuster

Bernhard Küster

3

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Tewis Bouwmeester

4

Tewis Bouwmeester

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Gerard Joberty

2

Gerard Joberty

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Miro Brajenovic

1

Journal of Biological Chemistry

Miro Brajenovic

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language of work or name

English

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publication date

26 March 2004

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published in

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volume

279

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page(s)

12804-11

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issue

13

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cites work

Asymmetric cell division

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

The road taken: past and future foundations of membrane traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Shaping the vertebrate body plan by polarized embryonic cell movements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Adaptation of core mechanisms to generate cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

PARsing embryonic polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Assembly of epithelial tight junctions is negatively regulated by Par6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Application of a rapid method (targeted display) for the identification of differentially expressed mRNAs following NGF-induced neuronal differentiation in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

A generic protein purification method for protein complex characterization and proteome exploration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Profiling core proteomes of human cell lines by one-dimensional PAGE and liquid chromatography-tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Probability-based protein identification by searching sequence databases using mass spectrometry data

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Error-tolerant identification of peptides in sequence databases by peptide sequence tags

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Miranda, a protein involved in neuroblast asymmetric division, is associated with embryonic centrosomes of Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Molecular characterization of the Drosophila Mo25 gene, which is conserved among Drosophila, mouse, and yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Analysis of PINCH function inDrosophilademonstrates its requirement in integrin-dependent cellular processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

LKB1, a protein kinase regulating cell proliferation and polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Global approaches to protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Functional organization of the yeast proteome by systematic analysis of protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200

Identification of genes required for cytoplasmic localization in early C. elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312171200