Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network (Q24301939)

Par-3 family cell polarity regulator

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Par-6 family cell polarity regulator beta

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sequestosome 1

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Deleted in malignant brain tumors 1

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epithelial cell differentiation

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author

Gerard Drewes

5

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Bernhard Kuster

Bernhard Küster

3

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Tewis Bouwmeester

4

Tewis Bouwmeester

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Gerard Joberty

2

Gerard Joberty

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Miro Brajenovic

1

Journal of Biological Chemistry

Miro Brajenovic

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publication date

26 March 2004

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language of work or name

English

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published in

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volume

279

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issue

13

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page(s)

12804-11

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cites work

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PARsing embryonic polarity

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Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

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PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

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The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein

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A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

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A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

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A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

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A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.

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Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

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Assembly of epithelial tight junctions is negatively regulated by Par6.

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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

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Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

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