Jump to content

sequestosome 1 (Q21106590)

From Wikidata
mammalian protein found in Homo sapiens
  • sequestosome-1
  • EBI3-associated protein of 60 kDa
  • p60
  • phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
  • autophagy receptor p62
  • EBIAP
  • EBI3-associated protein p60
  • oxidative stress induced like
  • ubiquitin-binding protein p62
  • SQSTM1
  • phosphotyrosine independent ligand for the Lck SH2 domain p62
  • Sequestosome-1 Protein
edit
Language Label Description Also known as
default for all languages
No label defined
    English
    sequestosome 1
    mammalian protein found in Homo sapiens
    • sequestosome-1
    • EBI3-associated protein of 60 kDa
    • p60
    • phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
    • autophagy receptor p62
    • EBIAP
    • EBI3-associated protein p60
    • oxidative stress induced like
    • ubiquitin-binding protein p62
    • SQSTM1
    • phosphotyrosine independent ligand for the Lck SH2 domain p62
    • Sequestosome-1 Protein

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    51 references
    retrieved
    8 April 2019
    stated in
    p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Disruption of FAT10-MAD2 binding inhibits tumor progression.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Huntingtin functions as a scaffold for selective macroautophagy
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Huntingtin functions as a scaffold for selective macroautophagy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human protein-protein interaction network: a resource for annotating the proteome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Towards a proteome-scale map of the human protein–protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Autophagy mediates degradation of nuclear lamina
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Sestrin2 promotes Unc‐51‐like kinase 1 mediated phosphorylation of p62/sequestosome‐1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nix is a selective autophagy receptor for mitochondrial clearance
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Global landscape of HIV-human protein complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Defining the human deubiquitinating enzyme interaction landscape
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATM functions at the peroxisome to induce pexophagy in response to ROS.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Network organization of the human autophagy system
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A directed protein interaction network for investigating intracellular signal transduction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Widespread macromolecular interaction perturbations in human genetic disorders
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
    GOA
    curator
    HUGO Gene Nomenclature Committee
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    identical protein binding
    determination method or standard
    IEA
    IPI
    6 references
    retrieved
    8 April 2019
    stated in
    Network organization of the human autophagy system
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A directed protein interaction network for investigating intracellular signal transduction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human protein-protein interaction network: a resource for annotating the proteome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Huntingtin functions as a scaffold for selective macroautophagy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IEA
    cell component
    autophagosome
    determination method or standard
    IBA
    IDA
    IEA
    8 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13501
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501
    determination method or standard
    IBA
    biological process

    Identifiers

    MeSH descriptor ID
    D000071456
    subject named as
    Sequestosome-1 Protein
    0 references
     
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    edit
                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q21106590&oldid=2383223183"