Parkin mono-ubiquitinates Bcl-2 and regulates autophagy (Q24301563)

GOA release 2020-03-11

protein ubiquitination

1 reference

Dong Chen

1

0 references

Feng Gao

2

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Bin Li

3

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Hongfeng Wang

4

0 references

Yuxia Xu

5

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Cuiqing Zhu

6

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Guanghui Wang

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

3 December 2010

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published in

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volume

285

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issue

49

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page(s)

38214-23

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cites work

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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Parkin ubiquitinates and promotes the degradation of RanBP2

19 March 2017

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

19 March 2017

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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

19 March 2017

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

19 March 2017

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

19 March 2017

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

19 March 2017

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

19 March 2017

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

19 March 2017

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

19 March 2017

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

19 March 2017

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

19 March 2017

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Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

19 March 2017

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Autophagy in the Pathogenesis of Disease

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Mechanisms underlying ubiquitination

19 March 2017

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The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

19 March 2017

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

19 March 2017

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

19 March 2017

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

19 March 2017

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

19 March 2017

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Identification of far upstream element-binding protein-1 as an authentic Parkin substrate

19 March 2017

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SEPT5_v2 is a parkin-binding protein

19 March 2017

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A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

19 March 2017

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Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation

19 March 2017

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The PINK1/Parkin pathway regulates mitochondrial morphology

19 March 2017

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Association between early-onset Parkinson's disease and mutations in the parkin gene

7 April 2017

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Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Parkin mediates the degradation-independent ubiquitination of Hsp70

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Parkin enhances mitochondrial biogenesis in proliferating cells

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Genetics of parkin-linked disease.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Complex relationship between Parkin mutations and Parkinson disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Etiology and pathogenesis of Parkinson's disease

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Linkage stratification and mutation analysis at the Parkin locus identifies mutation positive Parkinson's disease families

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992255

Complete genomic screen in Parkinson disease: evidence for multiple genes.

30 May 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.101469

Parkin mutations are frequent in patients with isolated early-onset parkinsonism.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.101469

Alterations in the common fragile site gene Parkin in ovarian and other cancers

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.101469

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.101469

Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism

21 January 2018

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12 December 2020

Genetic contributions to Parkinson's disease

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12 December 2020

Dopamine-induced apoptosis is inhibited in PC12 cells expressing Bcl-2

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12 December 2020

Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine

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12 December 2020