Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy (Q24301563)

https://api.crossref.org/works/10.1074/JBC.M110.101469

25 July 2024

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ubiquitin protein ligase binding

1 reference

GOA release 2020-03-11

protein ubiquitination

1 reference

3

Bin Li

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889974

25 July 2024

author name string

Dong Chen

1

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Feng Gao

2

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Hongfeng Wang

4

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Yuxia Xu

5

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Cuiqing Zhu

6

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Guanghui Wang

7

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language of work or name

English

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publication date

3 December 2010

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2 October 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889974

full work available at URL

25 July 2024

http://www.jbc.org/content/285/49/38214.full.pdf

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Portable Document Format

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20889974/pdf/?tool=EBI

25 July 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889974

http://intl.jbc.org/cgi/content/abstract/285/49/38214

25 July 2024

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20889974/?tool=EBI

25 July 2024

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https://europepmc.org/articles/PMC2992255

25 July 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889974

https://europepmc.org/articles/PMC2992255?pdf=render

25 July 2024

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content deliverer

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https://doi.org/10.1074/jbc.m110.101469

25 July 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889974

https://api.elsevier.com/content/article/PII:S002192582060686X?httpAccept=text/xml

25 July 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.101469

https://api.elsevier.com/content/article/PII:S002192582060686X?httpAccept=text/plain

25 July 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.101469

https://syndication.highwire.org/content/doi/10.1074/jbc.M110.101469

25 July 2024

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https://api.crossref.org/works/10.1074/JBC.M110.101469

Journal of Biological Chemistry

25 July 2024

published in

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volume

285

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issue

49

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page(s)

38214-23

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cites work

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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Parkin ubiquitinates and promotes the degradation of RanBP2

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

19 March 2017

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

19 March 2017

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

19 March 2017

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Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

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The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

19 March 2017

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Identification of far upstream element-binding protein-1 as an authentic Parkin substrate

19 March 2017

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SEPT5_v2 is a parkin-binding protein

19 March 2017

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A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

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Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation

19 March 2017

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Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

7 April 2017

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Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis

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A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

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Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

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27 September 2017

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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

27 September 2017

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Parkin mutations are frequent in patients with isolated early-onset parkinsonism

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Alterations in the common fragile site gene Parkin in ovarian and other cancers

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Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

21 January 2018

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12 December 2020

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