Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently (Q24292471)

GOA release 2020-03-11

chaperone binding

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GOA release 2020-03-11

toxicity

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author name string

Jen-Zen Chuang

1

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Hui Zhou

2

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Meicai Zhu

3

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Shi-Hua Li

4

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Xiao-Jiang Li

5

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Ching-Hwa Sung

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

31 May 2002

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published in

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volume

277

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page(s)

19831-8

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issue

22

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cites work

Molecular chaperones in cellular protein folding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

MSJ-1, a new member of the DNAJ family of proteins, is a male germ cell-specific gene product.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Heat shock protects cultured neurons from glutamate toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Genetic suppression of polyglutamine toxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Cloning, tissue expression, and chromosomal assignment of human MRJ gene for a member of the DNAJ protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

A human homologue of theEscherichia coliDnaJ heatshock protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Human cDNA encoding DnaJ protein homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Characterization of HDJ-2, a human 40 kD heat shock protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Isolation of a mouse cDNA encoding MTJ1, a new murine member of the DnaJ family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Structure and organisation of a murine gene encoding small heat-shock protein Hsp25.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Sequence and organization of genes encoding the human 27 kDa heat shock protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Alpha B-crystallin is a small heat shock protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Role of the J-domain in the cooperation of Hsp40 with Hsp70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

The chaperone function of hsp70 is required for protection against stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

A hitchhiker's guide to the human Hsp70 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Selective sparing of a class of striatal neurons in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

A null mutation in the human peripherin/RDS gene in a family with autosomal dominant retinitis punctata albescens

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

Neuropathological classification of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

Hyperthermia protects against light damage in the rat retina

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109613200

7 January 2021

Identifiers

DOI

10.1074/JBC.M109613200

1 reference

Consolidated OpenCitations Corpus – April 2017

4798676

4798676

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference