Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin (Q77906721)

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9 December 2019

title

Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin (English)

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9 December 2019

author name string

S H Li

1

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9 December 2019

A L Cheng

2

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9 December 2019

H Li

3

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9 December 2019

X J Li

4

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9 December 2019

publication date

1 July 1999

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9 December 2019

published in

Journal of Neuroscience

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9 December 2019

volume

19

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9 December 2019

page(s)

5159-5172

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9 December 2019

issue

13

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Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

9 December 2019

cites work

1 reference

12 December 2020

Selective sparing of a class of striatal neurons in Huntington's disease

1 reference

12 December 2020

Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis.

1 reference

12 December 2020

Neuronotypic differentiation results in reduced levels and altered distribution of synaptophysin in PC12 cells

1 reference

12 December 2020

Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor

1 reference

12 December 2020

Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif

1 reference

12 December 2020

Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse.

1 reference

12 December 2020

Huntington's disease: translating a CAG repeat into a pathogenic mechanism

1 reference

12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

12 December 2020

Staurosporine-induced neuronal apoptosis.

1 reference

12 December 2020

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

12 December 2020

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1 reference

12 December 2020

Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines

1 reference

12 December 2020

Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington's disease: a quantitative Golgi study.

1 reference

12 December 2020

Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats

1 reference

12 December 2020

Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase

1 reference

12 December 2020

Specific activation of a c-Jun NH2-terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine

1 reference

12 December 2020

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

1 reference

12 December 2020

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

1 reference

12 December 2020

Neurotrophin receptors: a window into neuronal differentiation

1 reference

12 December 2020

Neurotrophins live or let die: does p75NTR decide?

1 reference

12 December 2020

Cloning and expression of a glutamate transporter from mouse brain

1 reference

12 December 2020

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

12 December 2020

Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine.

1 reference

12 December 2020

The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor

1 reference

12 December 2020

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

1 reference

12 December 2020

Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins

1 reference

12 December 2020

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

1 reference

12 December 2020

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

12 December 2020

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

1 reference

12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

12 December 2020

Interaction of huntingtin-associated protein with dynactin P150Glued

1 reference

12 December 2020

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

1 reference

12 December 2020

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

12 December 2020

Transcriptional activation modulated by homopolymeric glutamine and proline stretches

1 reference

12 December 2020

Different mechanisms for inhibition of cell proliferation via cell cycle proteins in PC12 cells by nerve growth factor and staurosporine

1 reference

12 December 2020

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1 reference

12 December 2020

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

1 reference

12 December 2020

A huntingtin-associated protein enriched in brain with implications for pathology

1 reference

12 December 2020

A human HAP1 homologue. Cloning, expression, and interaction with huntingtin

1 reference

12 December 2020

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

1 reference

12 December 2020

The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human.

1 reference

12 December 2020

Rat metallothionein-1 structural gene and three pseudogenes, one of which contains 5'-regulatory sequences

1 reference

12 December 2020

Staurosporine causes epidermal growth factor to induce differentiation in PC12 cells via receptor up-regulation

1 reference

12 December 2020

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

1 reference

12 December 2020

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1 reference

12 December 2020

CRM1 is an export receptor for leucine-rich nuclear export signals

1 reference

12 December 2020

Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide

1 reference

12 December 2020

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1 reference

12 December 2020

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1 reference

12 December 2020

Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death

1 reference

12 December 2020

CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain

1 reference

12 December 2020

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

1 reference

12 December 2020

Evidence for a role of CRM1 in signal-mediated nuclear protein export

1 reference

12 December 2020

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

1 reference

12 December 2020

The complex pathology of trinucleotide repeats

1 reference

12 December 2020

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

12 December 2020

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

1 reference

12 December 2020

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy.

1 reference

12 December 2020

The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1

1 reference

12 December 2020

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

12 December 2020

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

1 reference

12 December 2020

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1 reference

12 December 2020

A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression

1 reference

12 December 2020

Ataxin-3 is transported into the nucleus and associates with the nuclear matrix

1 reference

12 December 2020

Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

1 reference

12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

12 December 2020

Mimicry and inhibition of nerve growth factor effects: interactions of staurosporine, forskolin, and K252a in PC12 cells and normal rat chromaffin cells in vitro

1 reference

12 December 2020

Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions.

1 reference

12 December 2020

Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase isoforms during neuronal apoptosis.

1 reference

12 December 2020

The high affinity uptake system for excitatory amino acids in the brain

1 reference

12 December 2020

Metallothioneins: proteins in search of function

1 reference

12 December 2020

Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length.

1 reference

12 December 2020

Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons

1 reference

12 December 2020

Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: an electron microscope study in the rat.

1 reference

12 December 2020

10.1523/JNEUROSCI.19-13-05159.1999

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377328%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

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9 December 2019

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