A perspective on mammalian upstream open reading frame function (Q21710700)

12 December 2020

Constraints on reinitiation of translation in mammals

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12 December 2020

Generation of protein isoform diversity by alternative initiation of translation at non-AUG codons.

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12 December 2020

Inflammation and metabolic disorders

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12 December 2020

Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex

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12 December 2020

Structural determinants of BRCA1 translational regulation

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12 December 2020

The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context

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12 December 2020

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

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12 December 2020

The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis

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12 December 2020

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.

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12 December 2020

Endothelial argininosuccinate synthase mRNA 5'-untranslated region diversity. Infrastructure for tissue-specific expression

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12 December 2020

Gene structure and chromosomal localization of mouse S-adenosylmethionine decarboxylase.

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12 December 2020

The inhibitory upstream open reading frame from mammalian S-adenosylmethionine decarboxylase mRNA has a strict sequence specificity in critical positions.

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12 December 2020

Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

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12 December 2020

Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene

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12 December 2020

Translation control of UCP2 synthesis by the upstream open reading frame.

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12 December 2020

An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.

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12 December 2020

Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance

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12 December 2020

Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages

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12 December 2020

Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation

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12 December 2020

Translational regulation of gene expression during conditions of cell stress

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12 December 2020

Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response

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12 December 2020

Internal ribosome entry site-mediated translation of a mammalian mRNA is regulated by amino acid availability.

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12 December 2020

Role of two upstream open reading frames in the translational control of oncogene mdm2.

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12 December 2020

Execution of nonsense-mediated mRNA decay: what defines a substrate?

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12 December 2020

Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

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12 December 2020

Bioinformatic analysis of post-transcriptional regulation by uORF in human and mouse

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12 December 2020

The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).

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12 December 2020

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

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12 December 2020

Evolution of alternative and constitutive regions of mammalian 5'UTRs.

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12 December 2020

Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes

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12 December 2020

A single-base deletion in the thrombopoietin (TPO) gene causes familial essential thrombocythemia through a mechanism of more efficient translation of TPO mRNA

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12 December 2020

HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA

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12 December 2020

Familial essential thrombocythemia associated with one-base deletion in the 5'-untranslated region of the thrombopoietin gene.

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12 December 2020

Translational regulation of GCN4 and the general amino acid control of yeast

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12 December 2020

Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frame

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12 December 2020

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

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12 December 2020

In vitro translation of the upstream open reading frame in the mammalian mRNA encoding S-adenosylmethionine decarboxylase.

1 reference

12 December 2020

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

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12 December 2020

Structural features in eukaryotic mRNAs that modulate the initiation of translation

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12 December 2020

Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.

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12 December 2020

Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems

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12 December 2020

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

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12 December 2020

Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation

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12 December 2020

Cell-specific translational regulation of S-adenosylmethionine decarboxylase mRNA. Dependence on translation and coding capacity of the cis-acting upstream open reading frame.

1 reference

12 December 2020

An upstream open reading frame within an IRES controls expression of a specific VEGF-A isoform

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12 December 2020

Translation reinitiation relies on the interaction between eIF3a/TIF32 and progressively folded cis-acting mRNA elements preceding short uORFs

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12 December 2020

eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA.

1 reference

12 December 2020

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

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12 December 2020

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

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12 December 2020

The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.

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12 December 2020

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation

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12 December 2020

Polyamine regulation of ribosome pausing at the upstream open reading frame of S-adenosylmethionine decarboxylase

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12 December 2020

uAUG and uORFs in human and rodent 5'untranslated mRNAs

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12 December 2020

Inhibition of vasopressin V1b receptor translation by upstream open reading frames in the 5'-untranslated region

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12 December 2020

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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12 December 2020

Analysis of small human proteins reveals the translation of upstream open reading frames of mRNAs

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12 December 2020

RNA binding protein/RNA element interactions and the control of translation

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12 December 2020

Inhibition of CCAAT/enhancer-binding protein alpha and beta translation by upstream open reading frames

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12 December 2020

Peptidomic discovery of short open reading frame-encoded peptides in human cells.

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12 December 2020

Translation initiation at non-AUG triplets in mammalian cells

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12 December 2020

Association between the 5' UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder

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12 December 2020

The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability.

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12 December 2020

Translational control of protein kinase Ceta by two upstream open reading frames

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12 December 2020

eIF3: a versatile scaffold for translation initiation complexes

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12 December 2020

The biological and therapeutic relevance of mRNA translation in cancer

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12 December 2020

Translation initiation at an ACG triplet in mammalian cells

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12 December 2020

Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner

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12 December 2020

CART classification of human 5' UTR sequences

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12 December 2020

Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes

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12 December 2020

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

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12 December 2020

Viral strategies to subvert the mammalian translation machinery

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12 December 2020

What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?

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12 December 2020

Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame

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12 December 2020

Cell-specific translation of S-adenosylmethionine decarboxylase mRNA. Regulation by the 5' transcript leader

1 reference

12 December 2020

Translational control of C/EBPalpha and C/EBPbeta isoform expression.

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12 December 2020

Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)

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12 December 2020

The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection

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12 December 2020

Translation start site multiplicity of the CCAAT/enhancer binding protein alpha mRNA is dictated by a small 5' open reading frame.

1 reference

12 December 2020

Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin

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12 December 2020

Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame

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12 December 2020

The scanning model for translation: an update

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12 December 2020

The upstream open reading frame of cyclin-dependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame

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12 December 2020

Diversity of translation start sites may define increased complexity of the human short ORFeome

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12 December 2020

The mechanism of eukaryotic translation initiation and principles of its regulation

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12 December 2020

Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites

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12 December 2020

Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias

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12 December 2020

5'UTR sequences of the glucocorticoid receptor 1A transcript encode a peptide associated with translational regulation of the glucocorticoid receptor.

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12 December 2020

Upstream ORF affects MYCN translation depending on exon 1b alternative splicing

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12 December 2020

Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma

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12 December 2020