Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay. (Q40552071)

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28 December 2019

title

Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay (English)

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28 December 2019

1

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Ana Luísa Silva

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Ana Morgado

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Paula Faustino

7

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28 December 2019

João Lavinha

8

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28 December 2019

Luísa Romão

10

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28 December 2019

author name string

Joana Pinto

3

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28 December 2019

Xinjun Ji

4

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28 December 2019

Fátima Almeida

6

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28 December 2019

Stephen A Liebhaber

9

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language of work or name

English

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publication date

25 May 2004

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Journal of Biological Chemistry

28 December 2019

published in

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28 December 2019

volume

279

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28 December 2019

page(s)

32170-32180

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28 December 2019

issue

31

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Emerging links between initiation of translation and human diseases

28 December 2019

cites work

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Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

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The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

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Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex

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The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

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Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1

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The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

21 January 2018

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The protein Mago provides a link between splicing and mRNA localization.

21 January 2018

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Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex

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Y14 and hUpf3b form an NMD-activating complex

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Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

21 January 2018

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Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)

21 January 2018

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Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

21 January 2018

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Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway

21 January 2018

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Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

21 January 2018

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Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway

21 January 2018

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Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes

21 January 2018

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Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells

21 January 2018

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

21 January 2018

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Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

21 January 2018

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Binary specification of nonsense codons by splicing and cytoplasmic translation

21 January 2018

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At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation

21 January 2018

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Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells

21 January 2018

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Infrequent translation of a nonsense codon is sufficient to decrease mRNA level

21 January 2018

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21 January 2018

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An activated 5' cryptic splice site in the human ALG3 gene generates a premature termination codon insensitive to nonsense-mediated mRNA decay in a new case of congenital disorder of glycosylation type Id (CDG-Id)

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M405024200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15161914%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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