Huntingtin interacting proteins are genetic modifiers of neurodegeneration (Q21145230)

Syntaxin 1A (brain)

1 reference

Synaptosomal-associated protein 25

1 reference

Ubiquitin specific peptidase 9, X chromosome

1 reference

Cullin 2

1 reference

Huntingtin

1 reference

Pyruvate kinase, muscle

1 reference

26S protease regulatory subunit 7

1 reference

17

Cornelia Kurschner

Cornelia

Kurschner

1 reference

17 August 2022

1

Linda S

Kaltenbach

Linda S Kaltenbach

1 reference

17 August 2022

18

Lisa M

Ellerby

Lisa M Ellerby

1 reference

17 August 2022

Eliana Romero

2

Eliana

Romero

1 reference

17 August 2022

Robert R Becklin

3

Robert R

Becklin

1 reference

17 August 2022

Rakesh Chettier

4

Rakesh

Chettier

1 reference

17 August 2022

Russell Bell

5

Russell

Bell

1 reference

17 August 2022

Amit Phansalkar

6

Amit

Phansalkar

1 reference

17 August 2022

Andrew Strand

7

Andrew

Strand

1 reference

17 August 2022

Cameron Torcassi

8

Cameron

Torcassi

1 reference

17 August 2022

Justin Savage

9

Justin

Savage

1 reference

17 August 2022

Anthony Hurlburt

10

Anthony

Hurlburt

1 reference

17 August 2022

Guang-Ho Cha

11

Guang-Ho

Cha

1 reference

17 August 2022

Lubna Ukani

12

Lubna

Ukani

1 reference

17 August 2022

Cindy Lou Chepanoske

13

Cindy Lou

Chepanoske

1 reference

17 August 2022

Yuejun Zhen

14

Yuejun

Zhen

1 reference

17 August 2022

Sudhir Sahasrabudhe

15

Sudhir

Sahasrabudhe

1 reference

17 August 2022

James Olson

16

James

Olson

1 reference

17 August 2022

John M Peltier

19

John M

Peltier

1 reference

17 August 2022

Juan Botas

20

Juan

Botas

1 reference

17 August 2022

Robert E Hughes

21

Robert E

Creative Commons Attribution 4.0 International

Hughes

1 reference

17 August 2022

language of work or name

English

0 references

publication date

11 May 2007

0 references

published in

PLOS Genetics

0 references

volume

3

0 references

page(s)

e82

0 references

issue

5

0 references

copyright license

start time

11 May 2007

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

BioGRID: a general repository for interaction datasets

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Human protein reference database--2006 update

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Towards a proteome-scale map of the human protein–protein interaction network

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

The synaptic vesicle cycle

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Functional organization of the yeast proteome by systematic analysis of protein complexes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

A comprehensive two-hybrid analysis to explore the yeast protein interactome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Probability-based protein identification by searching sequence databases using mass spectrometry data

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Normal huntingtin function: an alternative approach to Huntington's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Rapid identification of proteins by peptide-mass fingerprinting

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntingtin: alive and well and working in middle management

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Development of human protein reference database as an initial platform for approaching systems biology in humans

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

The hunt for huntingtin function: interaction partners tell many different stories

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntingtin interacts with a family of WW domain proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Comparative assessment of large-scale data sets of protein-protein interactions

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

A protein interaction network of the malaria parasite Plasmodium falciparum

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

28 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Structure and function of SNARE and SNARE-interacting proteins

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Genetic interaction of Lobe with its modifiers in dorsoventral patterning and growth of the Drosophila eye.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntington's disease: a synaptopathy?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

The use of transgenic and knock-in mice to study Huntington's disease.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

How reliable are experimental protein-protein interaction data?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Dying for a cause: invertebrate genetics takes on human neurodegeneration

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Mouse and fly models of neurodegeneration

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

The complete set of predicted genes from Saccharomyces cerevisiae in a readily usable form

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Genetic suppression of polyglutamine toxicity in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

HEAT repeats in the Huntington's disease protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Identification of genes that modify ataxin-1-induced neurodegeneration.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866352

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17500595

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Huntingtin: Alive and Well and Working in Middle Management

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17500595

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.0030082

1 reference

2581925

2581925

1 reference

1 reference

1 reference