Huntingtin: alive and well and working in middle management (Q28182055)

Science's STKE : signal transduction knowledge environment

Europe PubMed Central

title

Huntingtin: alive and well and working in middle management (English)

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1

Marcy E MacDonald

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language of work or name

English

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publication date

4 November 2003

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published in

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volume

2003

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page(s)

pe48

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issue

207

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cites work

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Structure of Pumilio reveals similarity between RNA and peptide binding motifs

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Huntingtin contains a highly conserved nuclear export signal

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Interaction of Huntington disease protein with transcriptional activator Sp1

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Genomic organization and alternative transcripts of the human PQBP-1 gene

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Neurological abnormalities in a knock-in mouse model of Huntington's disease

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

22 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2072003PE48

Comparison of ARM and HEAT protein repeats

22 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

22 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

Dysfunction of wild-type huntingtin in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

Intracellular Ca2+ signaling and human disease: the hunt begins with Huntington's.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

Homozygotes for Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2072003PE48