ELAV like RNA binding protein 1 (Q21113266)

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mammalian protein found in Homo sapiens

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
HuR
ELAVL1
ELAV-like protein 1
embryonic lethal, abnormal vision, drosophila, homolog-like 1
hu-antigen R
Hu antigen R

Language	Label	Description	Also known as
English	ELAV like RNA binding protein 1	mammalian protein found in Homo sapiens	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) HuR ELAVL1 ELAV-like protein 1 embryonic lethal, abnormal vision, drosophila, homolog-like 1 hu-antigen R Hu antigen R

Statements

1 reference

13 November 2019

UniProt protein ID

Splicing factor ELAV/Hu

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15717

RNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15717

Nucleotide-binding alpha-beta plait domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15717

HuR, RNA recognition motif 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

Splicing factor ELAV/Hu, RNA recognition motif 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

RNA recognition motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

8 April 2019

Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

protein binding

determination method

8 references

8 April 2019

Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Ubiquitin-mediated proteolysis of HuR by heat shock

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

determination method

6 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15717&geneProductId=UniProtKB:Q15717

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15717&geneProductId=UniProtKB:Q15717

determination method

26 September 2017

Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15717&geneProductId=UniProtKB:Q15717

determination method

26 September 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15717&geneProductId=UniProtKB:Q15717

determination method

26 September 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15717&geneProductId=UniProtKB:Q15717

determination method

26 September 2017

Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15717&geneProductId=UniProtKB:Q15717

determination method

nucleic acid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

double-stranded RNA binding

determination method

1 reference

8 April 2019

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

mRNA 3'-UTR AU-rich region binding

determination method

6 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

mRNA 3'-UTR binding

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

determination method

1 reference

8 April 2019

ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

determination method

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15717&geneProductId=UniProtKB:Q15717

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

cytoplasmic stress granule

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

biological process

regulation of mRNA stability

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

multicellular organism development

determination method

1 reference

1 January 2018

Localization of the human HuR gene to chromosome 19p13.2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

mRNA stabilization

determination method

3 references

8 April 2019

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

3'-UTR-mediated mRNA stabilization

determination method

2 references

mRNA splicing, via spliceosome

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

negative regulation of gene silencing by miRNA

determination method

1 reference

26 September 2017

Post-transcriptional regulation of Wnt co-receptor LRP6 and RNA-binding protein HuR by miR-29b in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15717&geneProductId=UniProtKB:Q15717

determination method

protein homooligomerization

determination method

1 reference

8 April 2019

ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

negative regulation of gene silencing by miRNA

determination method

3'-UTR-mediated mRNA stabilization

determination method

5 references

8 April 2019

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

8 April 2019

Role of N-myristoylation in stability and subcellular localization of the CLPABP protein.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15717

determination method

RNA recognition motif domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15717

Splicing factor ELAV/Hu, RNA recognition motif 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15717

HuR, RNA recognition motif 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15717

Identifiers

MeSH descriptor ID

subject named as

ELAV-Like Protein 1

0 references

D12.776.157.725.813.500.250

0 references

D12.776.664.962.813.500.250

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000385269

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385269

ENSP00000472197

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472197

ENSP00000470727

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470727

ENSP00000471011

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471011

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

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Multilingual sites(0 entries)

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