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Dicer 1, ribonuclease III (Q21111297)

From Wikidata
mammalian protein found in Homo sapiens
  • endoribonuclease Dicer
  • dicer 1, ribonuclease type III
  • dicer 1, double-stranded RNA-specific endoribonuclease
  • helicase with RNAse motif
  • DICER1
  • Dicer1, Dcr-1 homolog
  • helicase MOI
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    English
    Dicer 1, ribonuclease III
    mammalian protein found in Homo sapiens
    • endoribonuclease Dicer
    • dicer 1, ribonuclease type III
    • dicer 1, double-stranded RNA-specific endoribonuclease
    • helicase with RNAse motif
    • DICER1
    • Dicer1, Dcr-1 homolog
    • helicase MOI

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    25 references
    retrieved
    8 April 2019
    stated in
    Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MicroRNA silencing through RISC recruitment of eIF6
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RNA helicase A interacts with RISC in human cells and functions in RISC loading
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The role of PACT in the RNA silencing pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TWEAK Negatively Regulates Human Dicer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of human T‐cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference–mediated silencing in mammalian cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural insights into RNA processing by the human RISC-loading complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    HCV core protein interacts with Dicer to antagonize RNA silencing
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IPI
    ribonuclease III activity
    determination method or standard
    IEA
    EXP
    IDA
    7 references
    retrieved
    21 June 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IEA
    retrieved
    21 June 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IEA
    retrieved
    21 June 2018
    stated in
    Dicer recognizes the 5' end of RNA for efficient and accurate processing
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    21 June 2018
    stated in
    Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    EXP
    retrieved
    21 June 2018
    stated in
    Role for a bidentate ribonuclease in the initiation step of RNA interference
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    EXP
    retrieved
    21 June 2018
    stated in
    A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    EXP
    retrieved
    21 June 2018
    stated in
    Ribonuclease activity and RNA binding of recombinant human Dicer
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    EXP
    ribonuclease III activity
    determination method or standard
    EXP
    IBA
    IDA
    IEA
    8 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Dicer recognizes the 5' end of RNA for efficient and accurate processing
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IBA
    retrieved
    8 April 2019
    stated in
    Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    EXP
    retrieved
    8 April 2019
    stated in
    A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    EXP
    retrieved
    8 April 2019
    stated in
    Role for a bidentate ribonuclease in the initiation step of RNA interference
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    EXP
    retrieved
    8 April 2019
    stated in
    Ribonuclease activity and RNA binding of recombinant human Dicer
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    EXP
    cell component
    RISC-loading complex
    determination method or standard
    IDA
    6 references
    retrieved
    8 April 2019
    stated in
    RNA helicase A interacts with RISC in human cells and functions in RISC loading
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Structural insights into RNA processing by the human RISC-loading complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    In vitro reconstitution of the human RISC-loading complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    biological process
    pre-miRNA processing
    determination method or standard
    IDA
    5 references
    retrieved
    21 June 2018
    stated in
    TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    21 June 2018
    stated in
    Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    21 June 2018
    stated in
    A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    21 June 2018
    stated in
    In vitro reconstitution of the human RISC-loading complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    21 June 2018
    stated in
    Structure of precursor microRNA’s terminal loop regulates human Dicer’s dicing activity by switching DExH/D domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    pre-miRNA processing
    determination method or standard
    IBA
    IDA
    6 references
    retrieved
    8 April 2019
    stated in
    TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UPY3
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    In vitro reconstitution of the human RISC-loading complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Structure of precursor microRNA’s terminal loop regulates human Dicer’s dicing activity by switching DExH/D domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
    determination method or standard
    IBA

    Identifiers

    UniProt protein ID
    Q9UPY3
    0 references
    Ensembl protein ID
    ENSP00000343745
    0 references
    ENSP00000376783
    0 references
    ENSP00000435681
    0 references
    ENSP00000437256
    0 references
    ENSP00000444719
    0 references
    ENSP00000451041
    0 references
    ENSP00000433060
    0 references
    ENSP00000433926
    0 references
    ENSP00000452556
    0 references
    Freebase ID
    /m/02tcsv
    0 references
     
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21111297&oldid=2425654654"