BRCA1 DNA repair associated (Q17487737)

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mammalian protein found in Homo sapiens
  • RING finger protein 53
  • breast cancer 1, early onset
  • protein phosphatase 1, regulatory subunit 53
  • early onset breast cancer 1
  • Fanconi anemia, complementation group S
  • breast and ovarian cancer susceptibility protein 1
  • BRCA1
  • BRCA1/BRCA2-containing complex, subunit 1
  • breast cancer type 1 susceptibility protein
  • BRCA1 Protein
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Language Label Description Also known as
English
BRCA1 DNA repair associated
mammalian protein found in Homo sapiens
  • RING finger protein 53
  • breast cancer 1, early onset
  • protein phosphatase 1, regulatory subunit 53
  • early onset breast cancer 1
  • Fanconi anemia, complementation group S
  • breast and ovarian cancer susceptibility protein 1
  • BRCA1
  • BRCA1/BRCA2-containing complex, subunit 1
  • breast cancer type 1 susceptibility protein
  • BRCA1 Protein

Statements

molecular function
protein binding
determination method
IPI
64 references
retrieved
8 April 2019
stated in
EXD2 promotes homologous recombination by facilitating DNA end resection
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Highlight: BRCA1 and BRCA2 proteins in breast cancer
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
CCDC98 targets BRCA1 to DNA damage sites
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Identification of DBC1 as a transcriptional repressor for BRCA1
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
MERIT40 facilitates BRCA1 localization and DNA damage repair
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
ATM activation by ionizing radiation requires BRCA1-associated BAAT1
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
KIAA0101 interacts with BRCA1 and regulates centrosome number
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
CDK targets Sae2 to control DNA-end resection and homologous recombination
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
The BRCT Domain Is a Phospho-Protein Binding Domain
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Multifunctional transcription factor TFII-I is an activator of BRCA1 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of a carboxy-terminal BRCA1 interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
CCDC98 targets BRCA1 to DNA damage sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 interacts with FHL2 and enhances FHL2 transactivation function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
MDC1 is a mediator of the mammalian DNA damage checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
ATM activation by ionizing radiation requires BRCA1-associated BAAT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 is a negative modulator of the PRC2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
A mechanism for the suppression of homologous recombination in G1 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 participates in DNA decatenation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Structural determinants of the BRCA1 : estrogen receptor interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
retrieved
8 April 2019
stated in
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IPI
ubiquitin-protein transferase activity
determination method
IEA
IDA
5 references
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
determination method
IEA
retrieved
16 July 2018
stated in
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
16 July 2018
stated in
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
16 July 2018
stated in
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
16 July 2018
stated in
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
determination method
IDA
ubiquitin-protein transferase activity
determination method
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IEA
retrieved
8 April 2019
stated in
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IBA
cell component
BRCA1-BARD1 complex
determination method
IBA
IDA
5 references
retrieved
8 April 2019
stated in
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IBA
BRCA1-A complex
determination method
IBA
IDA
6 references
retrieved
8 April 2019
stated in
MERIT40 facilitates BRCA1 localization and DNA damage repair
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
GOA
curator
UniProt
UniProt protein ID
P38398
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
determination method
IBA
biological process
Commons category
BRCA1
0 references

Identifiers

MeSH descriptor ID
D019313
subject named as
BRCA1 Protein
0 references
MeSH tree code
D12.776.313.125
0 references
D12.776.624.776.100
0 references
D12.776.660.100
0 references
D12.776.744.100
0 references
D12.776.930.137
0 references
Ensembl protein ID
Freebase ID
/m/0256r1
0 references
PDB structure ID
 
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                Retrieved from "https://www.wikidata.org/w/index.php?title=Q17487737&oldid=2116631376"