clarithromycin (Q118551)

DrugBank

imported from Wikimedia project

17 November 2015

Clarithromycin structure.svg
620 × 481; 74 KB

1 reference

German Wikipedia

chemical formula

C₃₈H₆₉NO₁₃

1 reference

clarithromycin (English)

18 November 2016

canonical SMILES

CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O

1 reference

clarithromycin (English)

18 November 2016

isomeric SMILES

CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O

1 reference

World Health Organisation international non-proprietary name

clarithromycin (English)

18 November 2016

1 reference

14 February 2018

clarithromycin (English)

1 reference

clarithromycin (English)

medical condition treated

19 October 2016

clarithromycinum (Latin)

0 references

clarithromycine (French)

0 references

claritromicina (Spanish)

0 references

кларитромицин (Russian)

0 references

كلاريثروميسين (Arabic)

0 references

克拉霉素 (Chinese)

0 references

1 reference

13 December 2016

1 reference

13 December 2016

2 references

13 December 2016

upper respiratory tract infection

2 October 2018

1 reference

13 December 2016

1 reference

13 December 2016

2 references

13 December 2016

2 October 2018

2 references

13 December 2016

2 October 2018

2 references

13 December 2016

peripheral vascular disease

2 October 2018

1 reference

13 December 2016

staphylococcal infection

1 reference

bacterial infectious disease

13 December 2016

1 reference

2 October 2018

cellulitis

1 reference

2 October 2018

pneumonia

1 reference

2 October 2018

otitis

1 reference

Mycobacterium avium-intracellulare infection

2 October 2018

1 reference

susceptibility to severe influenza

2 October 2018

1 reference

2 October 2018

dental abscess

1 reference

2 October 2018

skin infection

2 references

2 October 2018

mycobacterium infectious disease

13 December 2016

Food and Drug Administration

30 October 1991

approved by

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/H1250JIK0A

http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050662s054,050698s033,050775s002lbl.pdf

streptococcal pharyngitis

Food and Drug Administration

30 October 1991

approved by

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/H1250JIK0A

http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050662s054,050698s033,050775s002lbl.pdf

Helicobacter pylori infectious disease

Food and Drug Administration

30 October 1991

approved by

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/H1250JIK0A

http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050662s054,050698s033,050775s002lbl.pdf

significant drug interaction

amiodarone

1 reference

High-priority drug–drug interactions for use in electronic health records

anagrelide

1 reference

High-priority drug–drug interactions for use in electronic health records

1 reference

High-priority drug–drug interactions for use in electronic health records

astemizole

1 reference

High-priority drug–drug interactions for use in electronic health records

azithromycin

1 reference

High-priority drug–drug interactions for use in electronic health records

bepridil

1 reference

High-priority drug–drug interactions for use in electronic health records

chloroquine

1 reference

High-priority drug–drug interactions for use in electronic health records

chlorpromazine

1 reference

High-priority drug–drug interactions for use in electronic health records

cisapride

1 reference

High-priority drug–drug interactions for use in electronic health records

(RS)-citalopram

1 reference

High-priority drug–drug interactions for use in electronic health records

cocaine

1 reference

High-priority drug–drug interactions for use in electronic health records

1 reference

High-priority drug–drug interactions for use in electronic health records

dofetilide

1 reference

High-priority drug–drug interactions for use in electronic health records

domperidone

1 reference

High-priority drug–drug interactions for use in electronic health records

dronedarone

1 reference

High-priority drug–drug interactions for use in electronic health records

1 reference

High-priority drug–drug interactions for use in electronic health records

erythromycin

1 reference

High-priority drug–drug interactions for use in electronic health records

escitalopram

1 reference

High-priority drug–drug interactions for use in electronic health records

flecainide

1 reference

High-priority drug–drug interactions for use in electronic health records

halofantrine

1 reference

High-priority drug–drug interactions for use in electronic health records

haloperidol

1 reference

High-priority drug–drug interactions for use in electronic health records

ibutilide

1 reference

High-priority drug–drug interactions for use in electronic health records

mesoridazine

1 reference

High-priority drug–drug interactions for use in electronic health records

(RS)-methadone

1 reference

High-priority drug–drug interactions for use in electronic health records

moxifloxacin

1 reference

High-priority drug–drug interactions for use in electronic health records

ondansetron

1 reference

High-priority drug–drug interactions for use in electronic health records

1 reference

High-priority drug–drug interactions for use in electronic health records

pimozide

1 reference

High-priority drug–drug interactions for use in electronic health records

probucol

1 reference

High-priority drug–drug interactions for use in electronic health records

procainamide

1 reference

High-priority drug–drug interactions for use in electronic health records

quinidine

1 reference

High-priority drug–drug interactions for use in electronic health records

sevoflurane

1 reference

High-priority drug–drug interactions for use in electronic health records

sotalol

1 reference

High-priority drug–drug interactions for use in electronic health records

sparfloxacin

1 reference

High-priority drug–drug interactions for use in electronic health records

(RS)-sulpiride

1 reference

High-priority drug–drug interactions for use in electronic health records

terfenadine

1 reference

High-priority drug–drug interactions for use in electronic health records

thioridazine

1 reference

High-priority drug–drug interactions for use in electronic health records

amiodarone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

moxifloxacin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

chlorpromazine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

zuclopenthixol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-hydroxyzine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-citalopram

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-sulpiride

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-methadone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

vardenafil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sunitinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dasatinib monohydrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

lapatinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sorafenib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sotalol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nilotinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bedaquiline

1 reference

A reference set of clinically relevant adverse drug-drug interactions

panobinostat

1 reference

A reference set of clinically relevant adverse drug-drug interactions

crizotinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

haloperidol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

saquinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

erythromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

quinine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pazopanib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

vandetanib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

venlafaxine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pimozide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tolterodine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

domperidone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

rifabutin

uveitis

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sildenafil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(Z)-Toremifene

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dronedarone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bosutinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cabozantinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ceritinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

methylprednisolone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dexamethasone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

prednisone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

budesonide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ivabradine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ergotamine

ergotism

1 reference

A reference set of clinically relevant adverse drug-drug interactions

amiodarone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-sulpiride

1 reference

A reference set of clinically relevant adverse drug-drug interactions

simvastatin

rhabdomyolysis

1 reference

A reference set of clinically relevant adverse drug-drug interactions

simvastatin

muscular disease

1 reference

A reference set of clinically relevant adverse drug-drug interactions

quetiapine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

seizure

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nausea

1 reference

A reference set of clinically relevant adverse drug-drug interactions

palpitation

1 reference

A reference set of clinically relevant adverse drug-drug interactions

vomiting

1 reference

A reference set of clinically relevant adverse drug-drug interactions

rac-warfarin

retroperitoneal hemorrhage

1 reference

A reference set of clinically relevant adverse drug-drug interactions

alfentanil

central respiratory depression

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fluticasone

Decreased circulating cortisol level

1 reference

A reference set of clinically relevant adverse drug-drug interactions

seizure

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nausea

1 reference

A reference set of clinically relevant adverse drug-drug interactions

vomiting

1 reference

A reference set of clinically relevant adverse drug-drug interactions

palpitation

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cyclosporine

kidney failure

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cyclosporine

cholestasis

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cyclosporine

paresthesia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

lopinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

thrombocytopenia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

leukopenia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fever

1 reference

A reference set of clinically relevant adverse drug-drug interactions

diarrhea

1 reference

A reference set of clinically relevant adverse drug-drug interactions

anemia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nifedipine

sinus bradycardia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nifedipine

hypotension

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nifedipine

acute kidney injury

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nimodipine

hypotension

1 reference

A reference set of clinically relevant adverse drug-drug interactions

digoxin

heart arrhythmia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

digoxin

nausea

1 reference

A reference set of clinically relevant adverse drug-drug interactions

digoxin

vomiting

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(Z)-Toremifene

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sorafenib

heart arrhythmia

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sotalol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atorvastatin

rhabdomyolysis

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atorvastatin

muscular disease

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pravastatin

rhabdomyolysis

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pravastatin

muscular disease

1 reference

A reference set of clinically relevant adverse drug-drug interactions

glyburide

hyperinsulinism

1 reference

A reference set of clinically relevant adverse drug-drug interactions

glimepiride

hyperinsulinism

1 reference

A reference set of clinically relevant adverse drug-drug interactions

glipizide

hyperinsulinism

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sufentanil

central respiratory depression

1 reference

A reference set of clinically relevant adverse drug-drug interactions

eliglustat

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ivabradine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dronedarone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dabrafenib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atazanavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atazanavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ritonavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

acenocoumarol

increased international normalised ratio

1 reference

A reference set of clinically relevant adverse drug-drug interactions

acenocoumarol

retroperitoneal hemorrhage

1 reference

A reference set of clinically relevant adverse drug-drug interactions

acenocoumarol

increased prothrombin time ratio

1 reference

A reference set of clinically relevant adverse drug-drug interactions

alfuzosin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tacrolimus

1 reference

A reference set of clinically relevant adverse drug-drug interactions

legal status (medicine)

boxed warning

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

LiverTox likelihood score

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

LiverTox toxicity likelihood category B

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Clarithromycin

last update

10 August 2017

mass

747.477 dalton

1 reference

protein synthesis inhibitor

clarithromycin (English)

18 November 2016

1 reference

2 references

5 March 2018

Medical Subject Headings

MeSH descriptor ID

D017291

xenobiotic-transporting ATPase inhibitor

15 March 2018

1 reference

5 March 2018

cytochrome P-450 CYP3A inhibitors

1 reference

Medical Subject Headings

15 March 2018

1 reference

Medical Subject Headings

15 March 2018

0 references

developmental toxicant

1 May 1997

1 reference

California Proposition 65 list of chemicals

21 February 2020

https://oehha.ca.gov/chemicals/clarithromycin

2 references

WHO Aware Classification

watch

1 reference

2023 ‎AWaRe classification‎

MCN code

2941.50.10

0 references

Commons category

Clarithromycin

0 references

Identifiers

InChI

InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

1 reference

clarithromycin (English)

18 November 2016

2 references

clarithromycin (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

81103-11-9

2 references

Global Substance Registration System

UNII

H1250JIK0A

clarithromycin (English)

18 November 2016

https://commonchemistry.cas.org/detail?cas_rn=81103-11-9

10 April 2021

1 reference

Clarithromycin (English)

18 November 2016

2 references

clarithromycin (English)

18 November 2016

Reaxys registry number

3581974

1 reference

clarithromycin (English)

19 October 2016

ChEBI ID

3732

mapping relation type

3 references

CLARITHROMYCIN (English)

18 November 2016

ChEBI release 2019-10-02

International Chemical Identifier

InChI

InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

1 reference

CLARITHROMYCIN (English)

18 November 2016

2 references

inferred from InChIKey

MSBNK-Athens_Univ-AU105301

1 reference

MassBank accession ID

0 references

MSBNK-Athens_Univ-AU105302

0 references

MSBNK-Athens_Univ-AU105303

0 references

MSBNK-Athens_Univ-AU105304

0 references

MSBNK-Athens_Univ-AU105305

0 references

MSBNK-Athens_Univ-AU105306

0 references

MSBNK-Athens_Univ-AU105307

0 references

MSBNK-Athens_Univ-AU105308

0 references

MSBNK-Athens_Univ-AU105309

0 references

MSBNK-Athens_Univ-AU105310

0 references

MSBNK-Athens_Univ-AU105311

0 references

SPLASH

splash10-0005-0300060900-61dad109d1b621f69b3b

0 references

splash10-0a4i-0900020000-0595f7fefa3c09c779d2

0 references

splash10-0a4i-0900000000-8a6bb2526f5f15604524

0 references

splash10-0a4i-0900000000-5d02e103d637084e4b49

0 references

splash10-0002-0000000900-9b3927ca525e74f19cec

0 references

splash10-052e-0800070900-da3f6b9dcca7ec506f23

0 references

splash10-00di-0000001900-bcb836ce99019295a00e

0 references

HSDB ID

8055

1 reference

Hazardous Substances Data Bank

28 October 2019

Clarithromycin (English)

10 May 2021

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.119.644

27 December 2018

ECHA Substance Infocard ID

(2R,3R,4S,5S,6R,7R,9R,11S,12R,13S,14S)-6-{[(2S,3R,4S,6R) -4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy} -14-ethyl-12,13-dihydroxy-4-{[(2R,4S,5S,6S)-5-hydroxy -4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7 -methoxy-3,5,7,9,11,13-hexamethyl -1-oxacyclotetradecane-2,10-dione (English)

quotation

CAS no.: 81103-11-9 (English)

100.119.644

1 reference