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cyclosporine (Q367700)

From Wikidata
chemical compound which is an immunosuppressant medication and natural product from the fungus Tolypocladium inflatum
  • OLO400
  • ciclosporin
  • cyclosporine A
  • 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]
  • 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  • Antibiotic S 7481F1
  • CsA
  • CyA
  • cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)
  • (R-[R*,R*-(E)])-cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
  • cyclosporin A
  • Cyclosporine
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Language Label Description Also known as
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No label defined
    English
    cyclosporine
    chemical compound which is an immunosuppressant medication and natural product from the fungus Tolypocladium inflatum
    • OLO400
    • ciclosporin
    • cyclosporine A
    • 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]
    • 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
    • Antibiotic S 7481F1
    • CsA
    • CyA
    • cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)
    • (R-[R*,R*-(E)])-cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
    • cyclosporin A
    • Cyclosporine

    Statements

    has use
    medication
    0 references
    chemical structure
    Ciclosporin.svg
    512 × 431; 16 KB
    0 references
    chemical formula
    C₆₂H₁₁₁N₁₁O₁₂
    1 reference
    stated in
    PubChem
    PubChem CID
    5284373
    language of work or name
    English
    title
    cyclosporin A (English)
    retrieved
    18 November 2016
    canonical SMILES
    CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
    1 reference
    stated in
    PubChem
    PubChem CID
    5284373
    language of work or name
    English
    title
    cyclosporin A (English)
    retrieved
    18 November 2016
    isomeric SMILES
    CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
    1 reference
    stated in
    PubChem
    PubChem CID
    5284373
    language of work or name
    English
    title
    cyclosporin A (English)
    retrieved
    18 November 2016
    medical condition treated
    significant drug interaction
    legal status (medicine)
    boxed warning
    1 reference
    reference URL
    https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
    title
    FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)
    mass
    1,201.841 dalton
    1 reference
    stated in
    PubChem
    PubChem CID
    5284373
    language of work or name
    English
    title
    cyclosporin A (English)
    retrieved
    18 November 2016
    Commons category
    Ciclosporin
    0 references

    Identifiers

    NDL Authority ID
    00576895
    0 references
    Reaxys registry number
    3647785
    1 reference
    stated in
    ChEBI
    ChEBI ID
    4031
    language of work or name
    English
    title
    cyclosporin A (English)
    retrieved
    3 October 2016
    CAMEO Chemicals ID
    20076
    0 references
    HSDB ID
    6881
    1 reference
    stated in
    Hazardous Substances Data Bank
    HSDB ID
    6881
    publication date
    28 October 2019
    title
    CYCLOSPORIN A (English)
    retrieved
    10 May 2021
    LiverTox ID
    Cyclosporine
    0 references
    NSC number
    290193
    0 references
    758194
    0 references
    EC number
    611-907-1
    1 reference
    stated in
    ECHA Substance Infocard database
    ECHA Substance Infocard ID
    100.119.569
    retrieved
    27 December 2018
    title
    (3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone (English)
    quotation
    CAS no.: 59865-13-3 (English)
    ECHA Substance Infocard ID
    100.119.569
    1 reference
    stated in
    ECHA Substance Infocard database
    ECHA Substance Infocard ID
    100.119.569
    retrieved
    27 December 2018
    title
    (3S,6S,9R,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone (English)
    quotation
    CAS no.: 59865-13-3 (English)
    MeSH descriptor ID
    D016572
    subject named as
    Cyclosporine
    0 references
    KNApSAcK ID
    C00001517
    1 reference
    stated in
    ChEBI
    ChEBI ID
    4031
    language of work or name
    English
    title
    cyclosporin A (English)
    retrieved
    3 October 2016
    KEGG ID
    D00184
    1 reference
    stated in
    ChEBI
    ChEBI ID
    4031
    language of work or name
    English
    title
    cyclosporin A (English)
    retrieved
    3 October 2016
    C05086
    1 reference
    stated in
    ChEBI
    ChEBI ID
    4031
    language of work or name
    English
    title
    cyclosporin A (English)
    retrieved
    3 October 2016
    PDB ligand ID
    EOV
    0 references
    Elhuyar ZTH ID
    032236
    0 references
    Microsoft Academic ID
    2779528694
    0 references
    2780178749
    0 references
    2910864246
    0 references
    NALT ID
    148746
    0 references
    YSO ID
    4093
    subject named as
    syklosporiini
    ciklosporin
    cyclosporine
    1 reference
    stated in
    YSO-Wikidata mapping project
    retrieved
    21 March 2022
     
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