Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase (Q112722863)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

title

Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

1 reference

dengue virus protein NS5

1 reference

based on heuristic

inferred from abstract

Zika virus

0 references

author

Radhakrishnan Padmanabhan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

Kyung H Choi

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

author name string

Eunhye Lee

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

Paul J Bujalowski

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

Tadahisa Teramoto

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

Keerthi Gottipati

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

Seth D Scott

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

publication date

5 May 2021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

page(s)

2530

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5

26 June 2022

cites work

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Supramolecular arrangement of the full-length Zika virus NS5

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Identification of the viral RNA promoter stem loop A (SLA)-binding site on Zika virus polymerase NS5

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

A 5' RNA element promotes dengue virus RNA synthesis on a circular genome

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Specific requirements for elements of the 5' and 3' terminal regions in flavivirus RNA synthesis and viral replication

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Infectious RNA transcripts from full-length dengue virus type 2 cDNA clones made in yeast

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

RNA elements within the 5' untranslated region of the West Nile virus genome are critical for RNA synthesis and virus replication

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Structure and function of the Zika virus full-length NS5 protein

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structure

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Sequence and secondary structure analysis of the 5'-terminal region of flavivirus genome RNA.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

The F1 motif of dengue virus polymerase NS5 is involved in promoter-dependent RNA synthesis

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Structure and Function of Flavivirus NS5 Methyltransferase

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Functional RNA elements in the dengue virus genome

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

RNA sequences and structures required for the recruitment and activity of the dengue virus polymerase

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

A novel in vitro replication system for Dengue virus. Initiation of RNA synthesis at the 3'-end of exogenous viral RNA templates requires 5'- and 3'-terminal complementary sequence motifs of the viral RNA.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Molecular basis for nucleotide conservation at the ends of the dengue virus genome.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Coot: model-building tools for molecular graphics

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

The Zika virus methyltransferase: structure and functions for drug design perspectives

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

A generic protocol for the expression and purification of recombinant RNA in Escherichia coli using a tRNA scaffold.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

RNA-dependent RNA polymerases from Flaviviridae

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Interactions between the Dengue Virus Polymerase NS5 and Stem-Loop A.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

1 November 2022

ViennaRNA Package 2.0

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Substitution of NS5 N-terminal domain of dengue virus type 2 RNA with type 4 domain caused impaired replication and emergence of adaptive mutants with enhanced fitness

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Expression, purification, and characterization of the RNA 5'-triphosphatase activity of dengue virus type 2 nonstructural protein 3.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Hepatitis C virus genomic RNA dimerization is mediated via a kissing complex intermediate

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Full-length Dengue virus RNA-dependent RNA polymerase-RNA/DNA complexes: stoichiometries, intrinsic affinities, cooperativities, base, and conformational specificities.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Processing of X-ray diffraction data collected in oscillation mode

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Subgenomic RNA from Dengue Virus Type 2 Suppresses Replication of Dengue Virus Genomes and Interacts with Virus-Encoded NS3 and NS5 Proteins

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Retroviral RNA Dimerization: From Structure to Functions.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Recombinant RNA technology: the tRNA scaffold.

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

Pervasive tertiary structure in the dengue virus RNA genome

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase

1 November 2022

1 reference

https://api.crossref.org/works/10.1038/S41467-021-22846-1

10.1038/S41467-021-22846-1

1 November 2022

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC8100141&resulttype=core&format=json

26 June 2022

1 reference