The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure (Q27490412)

inferred from abstract

Brian J Geiss

2

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author name string

Moheshwarnath Issur

1

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Isabelle Bougie

3

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Frédéric Picard-Jean

4

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Simon Despins

5

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Joannie Mayette

6

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Sarah E Hobdey

7

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Martin Bisaillon

Analysis of Flavivirus NS5 Methyltransferase Cap Binding

8

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language of work or name

English

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publication date

December 2009

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published in

RNA

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volume

15

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page(s)

2340-50

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issue

12

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cites work

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Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues

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Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5

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Structure and Function of Flavivirus NS5 Methyltransferase

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Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II

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An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

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Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining

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20 March 2017

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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Structure of a complex between a cap analogue and mRNA guanylyl transferase demonstrates the structural chemistry of RNA capping

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X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes

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Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene

20 March 2017

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mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae

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The guanylyltransferase domain of mammalian mRNA capping enzyme binds to the phosphorylated carboxyl-terminal domain of RNA polymerase II

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Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase

29 September 2017

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Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.

29 September 2017

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Structural organization of an encephalitic human isolate of Banna virus (genus Seadornavirus, family Reoviridae).

29 September 2017

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The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.

29 September 2017

1 reference

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A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

29 September 2017

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The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation

29 September 2017

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Cloning, expression, and characterization of avian reovirus guanylyltransferase

29 September 2017

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Structure, mechanism, and evolution of the mRNA capping apparatus

29 September 2017

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Viral and cellular mRNA capping: past and prospects

29 September 2017

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Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2.

29 September 2017

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An essential surface motif (WAQKW) of yeast RNA triphosphatase mediates formation of the mRNA capping enzyme complex with RNA guanylyltransferase

29 September 2017

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Expression and characterization of an RNA capping enzyme encoded by Chlorella virus PBCV-1

29 September 2017

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29 September 2017

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African swine fever virus guanylyltransferase

29 September 2017

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The mRNA (guanine-7-)methyltransferase domain of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli and structural and kinetic comparison to the intact capping enzyme.

29 September 2017

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Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP.

29 September 2017

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Mutational analysis of mRNA capping enzyme identifies amino acids involved in GTP binding, enzyme-guanylate formation, and GMP transfer to RNA.

29 September 2017

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Eukaryotic mRNA capping enzyme-guanylate covalent intermediate

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Mechanism of mRNA capping by vaccinia virus guanylyltransferase: characterization of an enzyme--guanylate intermediate

29 September 2017

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Reovirus guanylyltransferase is L2 gene product lambda 2.

29 September 2017

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In vitro synthesis of West Nile virus proteins indicates that the amino-terminal segment of the NS3 protein contains the active centre of the protease which cleaves the viral polyprotein after multiple basic amino acids

29 September 2017

1 reference

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Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein

29 September 2017

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Viral and cellular enzymes involved in synthesis of mRNA cap structure

29 September 2017

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Analyses of the terminal sequences of West Nile virus structural proteins and of the in vitro translation of these proteins allow the proposal of a complete scheme of the proteolytic cleavages involved in their synthesis

2 June 2018

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The expressed VP4 protein of bluetongue virus binds GTP and is the candidate guanylyl transferase of the virus

2 June 2018

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Rotavirus VP3 expressed in insect cells possesses guanylyltransferase activity

2 June 2018

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Metal ion-binding studies highlight important differences between flaviviral RNA polymerases

2 June 2018

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Poxvirus mRNA cap methyltransferase. Bypass of the requirement for the stimulatory subunit by mutations in the catalytic subunit and evidence for intersubunit allostery.

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Crystallization of the RNA guanylyltransferase of Chlorella virus PBCV-1.

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27 November 2018

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27 November 2018

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Unmatched masses in peptide mass fingerprints caused by cross-contamination: an updated statistical result.

27 November 2018

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An essential function of Saccharomyces cerevisiae RNA triphosphatase Cet1 is to stabilize RNA guanylyltransferase Ceg1 against thermal inactivation

27 November 2018

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Identification of a Novel Function of theAlphavirusCapping Apparatus

27 November 2018

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Intrinsic RNA (guanine-7) methyltransferase activity of the vaccinia virus capping enzyme D1 subunit is stimulated by the D12 subunit. Identification of amino acid residues in the D1 protein required for subunit association and methyl group transfer

27 November 2018

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Covalent catalysis in nucleotidyl transfer. A KTDG motif essential for enzyme-GMP complex formation by mRNA capping enzyme is conserved at the active sites of RNA and DNA ligases

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19850911

12 December 2020

inferred from PubMed ID database lookup

RNA capping by HeLa cell RNA guanylyltransferase. Characterization of a covalent protein-guanylate intermediate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19850911

12 December 2020

inferred from PubMed ID database lookup

Characterization of the reovirus lambda1 protein RNA 5'-triphosphatase activity

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19850911

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1261/RNA.1609709

1 reference

3038616

3038616

1 reference

1 reference

1 reference