Aurora kinase A (Q4822488)

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mammalian protein found in Homo sapiens
  • aurora kinase A
  • serine/threonine protein kinase 15
  • hARK1
  • serine/threonine-protein kinase aurora-A
  • aurora/IPL1-related kinase 1
  • Aurora-related kinase 1
  • Serine/threonine-protein kinase 15
  • AURKA
  • ARK-1
  • protein phosphatase 1, regulatory subunit 47
  • breast tumor-amplified kinase
  • aurora/IPL1-like kinase
  • aurora 2
  • serine/threonine-protein kinase 6
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Language Label Description Also known as
English
Aurora kinase A
mammalian protein found in Homo sapiens
  • aurora kinase A
  • serine/threonine protein kinase 15
  • hARK1
  • serine/threonine-protein kinase aurora-A
  • aurora/IPL1-related kinase 1
  • Aurora-related kinase 1
  • Serine/threonine-protein kinase 15
  • AURKA
  • ARK-1
  • protein phosphatase 1, regulatory subunit 47
  • breast tumor-amplified kinase
  • aurora/IPL1-like kinase
  • aurora 2
  • serine/threonine-protein kinase 6

Statements

molecular function
protein binding
determination method
IPI
33 references
retrieved
8 April 2019
stated in
Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Pitchfork regulates primary cilia disassembly and left-right asymmetry
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
A role for IkappaB kinase 2 in bipolar spindle assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Drugging MYCN through an allosteric transition in Aurora kinase A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphorylation profiling using an in situ proximity ligation assay: phosphorylation of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 in lung cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Systematic analysis of human protein complexes identifies chromosome segregation proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Astrin regulates Aurora-A localization.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
retrieved
8 April 2019
stated in
A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IPI
cell component
centrosome
determination method
IEA
IDA
TAS
7 references
retrieved
8 April 2019
stated in
Aurora A, centrosome structure, and the centrosome cycle
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IEA
retrieved
8 April 2019
stated in
CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IDA
retrieved
8 April 2019
stated in
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IDA
retrieved
8 April 2019
stated in
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis
GOA
curator
UniProt
UniProt protein ID
O14965
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IDA
retrieved
8 April 2019
stated in
Identification of Ski as a target for Aurora A kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965
determination method
IDA
biological process
physically interacts with
Gene Atlas image
PBB GE AURKA 204092 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

PDB structure ID
 
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